Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid

ABSTRACT: Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid

PROVIDER: PRJNA433368 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6681040.fastq.gz	Fastqsanger.gz
	SRR6681035.fastq.gz	Fastqsanger.gz
	SRR6681036.fastq.gz	Fastqsanger.gz
	SRR6681037.fastq.gz	Fastqsanger.gz
	SRR6681038.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells

Project description:This study examines the role of retinoic acid receptor (RAR) activity in type 1 innate lymphoid cells (ILC1s) by using Rosa26-RARα403 mice, that enable Cre-mediated inhibition of RAR activity in a dominant negative manner.

2022-07-31 | GSE205895 | GEO

Regulatory innate lymphoid cells control innate intestinal inflammation

Project description:Regulatory innate lymphoid cells control innate intestinal inflammation

| PRJNA394222 | ENA

Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells

Project description:Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells

| PRJNA848133 | ENA

Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function - Innate lymphoid cells

Project description:Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function - Innate lymphoid cells

| PRJEB46051 | ENA

Proteome of group 2 innate lymphoid cells (ILC2s) stimulated with IL33 and TL1A

Project description:We analyzed the total proteome of group 2 innate lymphoid cells (ILC2s) after different stimulation with interleukin-33 (IL-33), a cytokine playing a critical role in human asthma, and TL1A, a TNF-family cytokine also known to activate ILC2s. Upon combined stimulation with IL-33 plus TL1A, we show that lung ILC2s produce high amounts of IL-9 and acquire a transient ‘ILC9’ phenotype. This phenotype is characterized by simultaneous production of large amounts of type 2 cytokines (IL-5, IL-13 and IL-9), induction of the IL-2 receptor CD25 (Il2ra), and of the transcription factors IRF4, JunB and BATF, that form immune-specific complexes known to induce IL-9 expression.

2024-03-05 | PXD041987 | Pride

Understanding transcriptional identity in Innate Lymphoid Cells (ILC)

Project description:Understanding transcriptional identity in Innate Lymphoid Cells (ILC)

| PRJEB41498 | ENA

Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function - Innate lymphoid cells

Project description:Innate lymphoid cells (ILC) in the small intestine govern immune homeostasis and protect the host against gut pathogens. While distinct cell-intrinsic signals have been identified that determine ILC development and differentiation, it has remained unclear which cell population regulates ILC sustenance. Using unbiased single cell RNA transcriptomic analysis of intestinal fibroblasts, we have identified a specialized Ccl19-expressing fibroblastic reticular cell (FRC) population that underpins solitary intestinal lymphoid tissue (SILT) structures including cryptopatches and isolated lymphoid follicles. Conditional ablation of lymphotoxin-β receptor (LTβR) signalling in SILT FRC impeded the maturation of isolated lymphoid follicles and blocked ILC maintenance through the downregulation of IL-7, consequently resulting in the elevated susceptibility to bacterial infection. Moreover, specific Ltbr ablation in FRC during adulthood revealed that constant LTβR-dependent FRC-ILC interaction is required to maintain SILT structures and ILC populations. Taken together, our study unveils a critical intestinal FRC niche that secures protective gut immunity.

2022-02-12 | E-MTAB-10645 | biostudies-arrayexpress

ATAC-sequencing of innate lymphoid cells that were sorted from mouse skin

Project description:Purpose: Regulome analysis of skin innate lymphoid cells Methods: Innate lymphoid cells were sorted from epidermis, dermis and subcutis of adult B6 mice, respectively and subjected to transposition reaction and library preparation. Results: 20,869 accessible regulatory elements were detected Conclusions: This study reveals regulome landscape of skin innate lymphoid cells

2018-09-19 | GSE120126 | GEO

RNA-sequencing of innate lymphoid cells that were sorted from mouse skin

Project description:Purpose: Transcriptomic analysis of skin innate lymphoid cells Methods: Innate lymphoid cells were sorted from epidermis, dermis and subcutis of adult B6 mice, respectively and subjected to RNA isolation and library preparation. Results: 3,078 differentially expressed genes (fold change>2 and p-value<0.05) were detected Conclusions: This study reveals transcriptome landscape of skin innate lymphoid cells

2018-09-19 | GSE120128 | GEO

Single cell RNAseq of human innate lymphoid cells (ILC)

Project description:Single cell RNAseq of human innate lymphoid cells (ILC)

| PRJNA471290 | ENA