Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analyses in native eosinophils sorted from C57BL6J bone marrow

ABSTRACT: Gene expression analyses in native eosinophils sorted from C57BL6J bone marrow

PROVIDER: PRJNA433396 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6683835.fastq.gz	Fastqsanger.gz
	SRR6683836.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Gene expression analyses in native eosinophils sorted from C57BL6J bone marrow

Project description:We took a global approach to identify the genome-wide transcriptome in native murine eosinophils sorted from the bone marrow of C57BL6J mice at homeostasis.

2019-02-07 | GSE110299 | GEO

miR-223 Bone Marrow Derived Eosinophils

Project description:Gene expression profiling of bone marrow derived eosinophils from miR-223 wildtype or miR-223 deficient mice

2012-08-25 | E-MEXP-3350 | biostudies-arrayexpress

Effect of IL-33 in bone marrow derived eosinophils

Project description:This study aimed to investigate the effect of IL-33 in eosinophil in the context of arthritis. To address this, bone marrow derived eosinophils were generated and treated with or without IL-33 for 3 hours. Then total RNAs were subjected to the study.

2024-11-14 | GSE255597 | GEO

Expression profiles of sorted murine lung Eosinophils following allergen challenge

Project description:The eosinophil transcriptome analysis indicated a robust transcription change in eosinophils following allergen challenge in the lung. Eosinophils were FACS-sorted from Saline or OVA challenged lung with high purity and then subjected to genome-wide RNA microarray

2014-05-19 | E-GEOD-57757 | biostudies-arrayexpress

Effect of IL-33 in bone marrow derived eosinophils

Project description:Effect of IL-33 in bone marrow derived eosinophils

| PRJNA1075704 | ENA

Transcriptome Sequencing of mice eosinophils upon Listeria monocytogenes (L.m.) infection

Project description:Mature eosinophils were differentiated from mouse bone marrow progenitors We performed transcriptome sequencing on Listeria monocytogenes infected eosinophils and resting eosinophils to shed light on the transcriptional changes of cytokines and chemokines.

2024-01-31 | GSE220480 | GEO

C57Bl6J retina lysates

Project description:C57Bl6J retina lysates

| PRJNA870946 | ENA

Comparison of coding RNA expression in steady-state and in response to IL33 and IL5 stimulation in bone marrow eosinophils from IL5-deficient and wild-type littermates

Project description:Aim of the experiment was to assess differences in expression of coding RNA between bone marrow eosinophils arising in IL-5 knock-out mice (C57BL/6-Il5tm1Kopf/J) or wild-type littermates and their response to cytokine stimulation. Bone marrow eosinophils were sorted by FACS submitted to RNA-seq immediately or after 4 hours of stimulation with IL-5 and IL-33 in culture plates.

2021-12-17 | E-MTAB-10188 | biostudies-arrayexpress

Bacterial skin infection primes bone marrow eosinophils to promote allergic skin-lung crosstalk

Project description:Microbial exposure at barrier interfaces drives development and balance of the immune system, but the consequences of local infections for systemic immunity and secondary inflammation are unclear. Here, we show that dermal exposure to the bacterium Staphylococcus aureus persistently shapes the immune system of mice with specific impact on progenitor and mature bone marrow neutrophil and eosinophil populations. The infection-imposed changes in eosinophils were long-lasting with functional changes associated with epigenetic and metabolic reprogramming, indicative of trained immunity. Bacterial exposure enhanced dermal allergic sensitization and resulted in exacerbated allergen-induced lung inflammation. S. aureus-mediated reprogramming of bone marrow eosinophils was driven by the alarmin interleukin 33 and the complement cleavage fragment C5a. Our study highlights the systemic impact of skin inflammation and reveals eosinophil progenitor training and organ-crosstalk mechanisms that modulate systemic responses to allergens.

2025-02-12 | GSE287520 | GEO

Tissue adaptaion of intestinal eosinophils in mice

Project description:To determine how eosinophils adapt to the intestinal environment, eosinophils were sorted from the bone marrow and small intestine and compared by RNA sequencing. We show here that intestinal eosinophils were specifically adapted to their environment and underwent substantial transcriptomic changes. Intestinal eosinophils upregulated genes relating to the immune response and cell-cell communication, extracellular matrix components and metalloproteases, and the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor with broad functions in intestinal homeostasis.

2022-02-25 | GSE185070 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data