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Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 CUMULUS]

ABSTRACT: Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 CUMULUS]

PROVIDER: PRJNA434814 | ENA |

REPOSITORIES: ENA

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Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 CUMULUS]

Project description:This study assessed the global gene-level expression of human cumulus granulosa cells.

2021-02-10 | GSE110921 | GEO

Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

Project description:Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

| PRJNA434818 | ENA

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 CUMULUS]

Project description:Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 CUMULUS]

| PRJNA434816 | ENA

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 CUMULUS]

Project description:This study assessed the global gene-level expression of human cumulus granulosa cells.

2021-02-10 | GSE110918 | GEO

Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

Project description:This study assessed the global gene-level expression of human mural granulosa cells.

2021-02-10 | GSE110922 | GEO

Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

Project description:Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

| PRJNA434815 | ENA

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of a Mixture of 10 PBDE Congeners Quantified from Follicular Fluid [10-PBDE_CUMULUS]

Project description:This study assessed the global gene-level expression of human cumulus granulosa cells.

2021-02-10 | GSE110916 | GEO

Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

Project description:This study assessed the global gene-level expression of human mural granulosa cells.

2021-02-10 | GSE110919 | GEO

Differential Gene Expression of Human Cumulus Granulosa and Mural Granulosa Cells in ICSI Patients

Project description:Differential Gene Expression of Human Cumulus Granulosa and Mural Granulosa Cells in ICSI Patients

2021-02-10 | GSE110924 | GEO

Transcriptomic analysis of HepG2 cells treated with BDE-47, BDE-99, BDE-209 and their ternary mixture at 1nM as a dietary relevant concentration

Project description:Polybrominated diphenyl ethers (PBDEs) are persistent organic chemicals implied as flame re-tardants. Humans are mainly exposed to BDE-47, -99 and -209 congeners by diet. PBDEs are metabolic disruptors with liver as main target organ. To investigate their mode of action at a human relevant concentration, we exposed HepG2 cells to these congeners and their mixture at 1 nM for 72h, analyzing their transcriptomic and proteomic profiles. KEGG pathways and GSEA Hallmarks enrichment analyses evidenced that BDE-47 disrupted the glucose metabolism and Hypoxia pathway; all the congeners and the MIX affected lipid metabolism and signaling Hallmarks regulating metabolism as mTORC1 and PI3K/AKT/MTOR. These results were confirmed by glucose secretion depletion and increased lipid accumulation, especially in BDE-47 and -209 treated cells. These congeners also affected the EGFR/MAPK signaling; further, BDE-47 enriched the Estrogen pathway. Interestingly, BDE-209 and the MIX increased ERα gene expression, whereas all the congeners and the MIX induced ERβ and PPARγ. We also found that PBDEs modulated several lncRNAs and that HNRNAP1 represented a central hub in all the four interaction networks. Overall, despite the low concentration used, the PBDEs investigated affected glucose and lipid metabolism with different underlying modes of action, as highlighted by the integrated omics analysis. These results may support the mechanism-based risk assessment of these compounds in relation to liver metabolism disruption.

2022-10-28 | GSE216590 | GEO

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