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MRNA sequence Analysis of Apocynin treated MKN45

ABSTRACT: mRNA sequence Analysis of Apocynin treated MKN45

PROVIDER: PRJNA437294 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6814780_1.fastq.gz	Fastqsanger.gz
	SRR6814780_2.fastq.gz	Fastqsanger.gz
	SRR6814781_1.fastq.gz	Fastqsanger.gz
	SRR6814781_2.fastq.gz	Fastqsanger.gz
	SRR6814778_1.fastq.gz	Fastqsanger.gz

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mRNA sequence Analysis of Apocynin treated MKN45

Project description:Noxo1, a component of NADPH oxidase 1 (NOX1) complex, is upregulated in gastric cancer cells in a inflammation-dependent manner, and plays an important role in tumorigenesis (Oncogene, 33: 3820, 2014). To examine the mechanism of NOX1/ROS signaling in tumorigenesis, MKN45 gastric cancer cells were treated with apocynin, an inhibitor for NOX, and their gene expression was examined by RNA sequencing. Based on expression data, Sox2 was shown to be suppressed by apocynin, suggesting a role of Sox2 in a inflammation-associated gastric tumorigenesis.

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