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Altered adipose lipid mobilization predicts long-term weight gain and impaired glucose metabolism

ABSTRACT: Altered adipose lipid mobilization predicts long-term weight gain and impaired glucose metabolism

PROVIDER: PRJNA449938 | ENA |

REPOSITORIES: ENA

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Altered adipose lipid mobilization predicts long-term weight gain and impaired glucose metabolism

Project description:Factors predicting body weight gain and associated disturbed glucose metabolism remain to be established. Here we assessed the role of subcutaneous adipocyte lipid mobilization (lipolysis) in spontaneous long-term (>10 years) body weight changes. In two independent clinical cohorts we found that low stimulated lipolysis at baseline correlated inversely with body mass index changes over time. Disturbed lipolysis gave odds ratios of ≥4.6 for weight gain and ≥3.2 for development of insulin resistance and impaired fasting glucose/type 2 diabetes. Baseline adipose mRNA expression of a set of established lipolysis-regulating genes was lower in weight gainers.

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Protection against overfeeding-induced weight gain in mice is preserved in obesity but does not require FGF21 or MC4R

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Integrative Personal Omics Profiles During Periods of Weight Gain and Loss

Project description:A longitudinal study of PBMCs from patients during periods of weight gain and loss in humans was performed.

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