Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Longitudinal Study of Bone and Endocrine Disease in Children with MPS I, II, and VI: A Multicenter Study of the Lysosomal Disease Network - LDN 6705

ABSTRACT: Longitudinal Study of Bone and Endocrine Disease in Children with MPS I, II, and VI: A Multicenter Study of the Lysosomal Disease Network - LDN 6705

PROVIDER: PRJNA449985 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Longitudinal Study of Bone and Endocrine Disease in Children with MPS I, II, and VI: A Multicenter Study of the Lysosomal Disease Network - LDN 6705

Project description:Longitudinal Study of Bone and Endocrine Disease in Children with MPS I, II, and VI: A Multicenter Study of the Lysosomal Disease Network - LDN 6705

| PRJNA449984 | ENA

Characterizing the Neurobehavioral Phenotype(s) in MPS III (Pilot Study) - LDN 6707

Project description:Characterizing the Neurobehavioral Phenotype(s) in MPS III (Pilot Study) - LDN 6707

| PRJNA378817 | ENA

Multicenter AIDS Cohort Study

Project description:Multicenter AIDS Cohort Study

| PRJNA671262 | ENA

Multicenter AIDS Cohort Study

Project description:Multicenter AIDS Cohort Study

| PRJNA671263 | ENA

Multicenter Study of Hydroxyurea (MSH)

Project description:Multicenter Study of Hydroxyurea (MSH)

| PRJNA701326 | ENA

Multicenter Study of Hydroxyurea (MSH)

Project description:Multicenter Study of Hydroxyurea (MSH)

| PRJNA701327 | ENA

Longitudinal Studies of Brain Structure and Function in MPS Disorders - LDN 6703

Project description:Longitudinal Studies of Brain Structure and Function in MPS Disorders - LDN 6703

| PRJNA378694 | ENA

Microarray analysis of Normal and MPS VII mouse aorta

Project description:Mucopolysaccharidosis VII (MPS VII) is due to mutations within the gene encoding the lysosomal enzyme beta-glucuronidase, and results in the accumulation of glycosaminoglycans. MPS VII causes aortic dilatation and elastin fragmentation. In this study we performed microarray analysis of ascending aortas from normal and MPS VII mice, trying to find out possible genes responsible for the phenotype observed. In addition, during our breeding strategy, we noticed that some MPS VII mice had less dilated aortas, and we proposed that an yet-unidentified gene could be responsible for the difference observed. We therefore included in the analysis two MPS VII mice with aortas that were not dilated. Total RNA extracted from ascending aortas from 3 Normal mice, 3 MPS VII mice with dilated aortas and 2 MPS VII mice with aortas that were not dilated.

2011-10-09 | E-GEOD-30657 | biostudies-arrayexpress

Expression data of Normal versus Mutant MPS VII C3H mouse

Project description:We used microarray to detect pathway differences in the various brain regions in a monogenic in mucopolysaccharidosis type VII ( MPS VII ), a mouse model of a lysosomal storage disease A number of changes revealed unexpected system and process alterations, such as upregulation of the immune system with few inflammatory changes (a significant difference from the closely related MPS IIIb model), down-regulation of major oligodendrocyte genes even though white matter changes are not a feature histopathologically, and a plethora of developmental gene changes. 94 samples, no replicates, made up of half normals and half MPS mutant mice for the MPS VII mutation backcrossed on a C3h-heouj background

2012-12-01 | E-GEOD-34071 | biostudies-arrayexpress

Microarray analysis of Normal and MPS VII mouse aorta

2011-10-10 | GSE30657 | GEO