Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional alteration after ionizing radiation exposure in human fibroblasts, iPSCs and NPCs

ABSTRACT: Transcriptional alteration after ionizing radiation exposure in human fibroblasts, iPSCs and NPCs

PROVIDER: PRJNA450083 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7000800_1.fastq.gz	Fastqsanger.gz
	SRR7000800_2.fastq.gz	Fastqsanger.gz
	SRR7000801_1.fastq.gz	Fastqsanger.gz
	SRR7000801_2.fastq.gz	Fastqsanger.gz
	SRR7000802_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Transcriptional alteration after ionizing radiation exposure in human fibroblasts, iPSCs and NPCs

Project description:RNA sequencing was performed to investigate ionizing radiation-dependent transcriptional change in human pluripotent cells and differentiated cells.

2019-06-30 | GSE113125 | GEO

CNA analysis of ionizing radiation related basal cell carcinoma

Project description:gDNA from patient samples with multiple basal cell carcinomas and possible exposure to ionizing radiation was hybridized Vs. GM12878 gDNA to assess CNAs. We aimed to find a possible common aberration pattern related to ionizing radiation or a rare metastasis.

2017-10-02 | GSE97334 | GEO

Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation

Project description:Tardigrades can survive remarkable doses of ionizing radiation, up to about 1000 times the lethal dose for humans. How they do so is incompletely understood. We found that the tardigrade Hypsibius exemplaris suffers DNA damage upon gamma irradiation, but damage is repaired. We show that tardigrades have a specific and robust response to ionizing radiation: irradiation induces a rapid, dramatic upregulation of many DNA repair genes. By expressing tardigrade genes in bacteria, we validate that increased expression of some repair genes can suffice to increase radiation tolerance. We show that at least one such gene is necessary for tardigrade radiation tolerance. Tardigrades’ ability to sense ionizing radiation and massively upregulate specific DNA repair pathway genes may represent an evolved solution for maintaining DNA integrity.

2024-12-13 | PXD047724 | Pride

Ionizing Radiation-induced expression response in Drosophila Larvae

Project description:Genome-wide expression analysis comparison with and without ionizing radiation in p53 mutant and wild type Drosophila larvae

2012-04-18 | GSE37404 | GEO

Transcriptional response of lymphoblastoid cells to ionizing radiation

Project description:Time series for gene expression changes following 3 Gy and 10 Gy of ionizing radiation exposure. Keywords: time-course

2003-10-08 | GSE701 | GEO

Single-cell transcription profiling in KS1 patient iPSCs and NPCs

Project description:We conducted single-cell RNA-seq (scRNA-seq) in human-derived induced pluripotent stem cells (iPSCs) and neural progenitor cells (NPCs) generated from Kabuki syndrome 1 (KS1) patients and healthy controls

2019-02-04 | GSE126027 | GEO

Ionizing Radiation-induced expression response in Drosophila Larvae

Project description:Genome-wide expression analysis comparison with and without ionizing radiation in p53 mutant and wild type Drosophila larvae Genome-wide expression analysis comparison with and without ionizing radiation in p53 mutant (p53^5A-1-4) and wild type (y^1 w^1118) Drosophila third instar larvae. 4000R of X-rays used in IR-treated Drosophila. Analyzed 2hr and 18hr after exposure with age-matched larvae in non-treated controls.

2012-04-17 | E-GEOD-37404 | biostudies-arrayexpress

SRSF1 knockdown in HEK293T cells with ionizing radiation

Project description:The goal of the study is to identify differentially expressed isoforms in response to SRSF1 knockdown and/or ionizing radiation in HEK293T cells

2024-09-30 | GSE242550 | GEO

CT26 Proteome and Immunopeptidome treated with Ionizing Radiation

Project description:This project explored the relationship between ionizing radiation and antigen presentation using both proteomic and immunopeptidomics methodologies. We investigated the radiation-specific changes which occur in the colorectal tumor cell proteome associated with changes in dose and time after irradiation. We used this data to observe the changes in key regulators and effector proteins of the antigen processing and presentation machinery. Furthermore, a parallel immunopeptidomics analysis enabled a peptide-level assessment of antigen presentation to correlate changes observed in the proteome thereby defining a radiation-specific peptide repertoire. A nuanced relationship between protein expression and antigen presentation was observed where radiation-induced changes in proteins do not always correlate with increased presentation of associated peptides. Furthermore, a neoantigen which increases in the context of radiation was characterised. This study provides new insights into how radiation enhances antigen processing and presentation that could be suitable for the development of combinatorial therapies.

2022-10-04 | PXD032003 | Pride

Gene expression profile of FMR1-KO iPSCs-derived NPCs

Project description:Gene expression profile of FMR1-KO iPSCs-derived NPCs

| PRJNA427694 | ENA