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Anti-fatigure properties of Sasa quelpaertensis leaf extracts in mice

ABSTRACT: Anti-fatigure properties of Sasa quelpaertensis leaf extracts in mice

PROVIDER: PRJNA453928 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7073310.fastq.gz	Fastqsanger.gz
	SRR7073308.fastq.gz	Fastqsanger.gz
	SRR7073309.fastq.gz	Fastqsanger.gz

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Anti-fatigure properties of Sasa quelpaertensis leaf extracts in mice

Project description:The study aimed the effects of Sasa quelpaertensis leaf hot water extract (SQH) on anti-fatigue function and the global gene expression pattern in muscle tissue. When rat skeletal muscle cells were cultured in hypoxic condition, the levels of lactate and lactate dehydrogenase (LDH) was increased approximately more than 2-fold, but SQH decreased effectively these levels. Thus, we assessed the exercise and fatigue recovery function using several physical biomarkers such as glycogen, lactate and so on in high intensity exercise mice. The mice were divided into three groups; Normal Control (NC), Exercise Control (EC), and Exercise SQH (ES) by oral administered at 50mg/kg/day for 7 days. After excessive swimming,the ES group showed increases serum glucose and decrease serum lactate than EC group. Lactate content in muscle was lower ES group than EC group. Glycogen contents in muscle and liver were higher ES group than EC group. And, SQH administration increased the expression of phospho-Acetyl-CoA (p-ACC), and reduced the expression of phospho-AMP-activated protein kinase (p-AMPK) and GLUT4 in in-vivo model. Also, genome wide expression profiles of tissue were determined by RNA sequencing. SQH up-regulates and down-regulates several genes associated with fatigue. In conclusion, this study suggested that SQH are effective for anti-fatigue agent.

2021-04-24 | GSE113759 | GEO

Effects of Morus alba L. (Mulberry) Leaf Extract in Hypercholesterolemic Mice on Suppression of Cholesterol Synthesis

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Project description:To investigate effects of intake of mulberry leaf extracts on hypercholesterolemia, we performed gene expression profiling on rat liver by microarray analysis. Microarray analysis revealed that mulberry leaf extracts up-regulated the gene expression involved in suppression of cholesterol synthesis and stimulation of innate-adaptive Immunity. Mice were fed a high-cholesterol diet without/with orally administration of mulberry leaf extracts for 4 weeks. Livers were taken for RNA extraction and hybridization on Agilent microarrays.

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