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Transcriptional responses in whole blood of healthy adult volunteers experimentally challenged with S. Paratyphi

ABSTRACT: Transcriptional responses in whole blood of healthy adult volunteers experimentally challenged with S. Paratyphi

PROVIDER: PRJNA459561 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7119040_1.fastq.gz	Fastqsanger.gz
	SRR7119040_2.fastq.gz	Fastqsanger.gz
	SRR7119050_1.fastq.gz	Fastqsanger.gz
	SRR7119050_2.fastq.gz	Fastqsanger.gz
	SRR7119060_1.fastq.gz	Fastqsanger.gz

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Transcriptional responses in whole blood of healthy adult volunteers experimentally challenged with S. Paratyphi

Project description:This studies describes the transcriptional response in whole blood derived from healthy adult volunteers experimentally infected with S. Paratyphi A. Samples were collected at pre-challenge baseline (Group: CTRL), at day 7 after challenge in those participants who stayed well over 14 days following challenge (Group: suspected Enteric Fever - sEF). Participants who developed signs of enteric fever were sampled at the time of inititiation of antibiotics (Group: EF).In this group diagnosis was confirmed by blood culture positive for S. Paratyphi (SPT). Antibiotic therapy commenced at time of diagnosis or at day 14 after challenge in those who did not develop symptoms. The clinical results of this study have been published in: Dobinson et al. Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model. Clin Infect Dis. 2017 Apr 15;64(8):1066-1073.

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Project description:In this study, whole blood samples were used to determine the gene expression of healthy adult volunteers experimentally challenged with S. Typhi Quailes strain. Samples were collected at baseline (pre-challenge; Group: CTRL) and 7 days after challenge (Group: sEF) in individuals who did not reach diagnostic criteria. In those reaching the diagnostic endpoint (typhoid fever; Group: EF) the sample on the day of diagnosis when antibiotic treatment commenced was taken. These samples were derived from the placebo arm of a recent a Single Centre, Randomised, Doubleblind, Placebo Controlled Study to Evaluate M01ZH09 in a Healthy Adult Challenge Model, Using Ty21a Vaccine as a Positive Control. Darton et al. PMID: 27533046.

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