Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: DBA/2J Muscle macrophages expression profile

PROVIDER: PRJNA471894 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7180180.fastq.gz	Fastqsanger.gz
	SRR7180190.fastq.gz	Fastqsanger.gz
	SRR7180181.fastq.gz	Fastqsanger.gz
	SRR7180191.fastq.gz	Fastqsanger.gz
	SRR7180182.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 33

Similar Datasets

Mus musculus

Project description:Gene expression profiling in DBA/2J glaucoma

| PRJNA135129 | ENA

Mus musculus

Project description:Gene Expression profiling in DBA/2J glaucoma

| PRJNA156985 | ENA

Mus musculus

Project description:Gene expression profile of the age-related hearing loss cochlea in DBA/2J mice

| PRJNA97781 | ENA

The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix

Project description:Genetic background shifts the severity of muscular dystrophy. In mice, the DBA/2J strain confers a more severe muscular dystrophy phenotype, whereas the Murphy’s Roth Large (MRL) strain has “super-healing” properties that reduce fibrosis. A comparative analysis of the Sgcg null model of Limb Girdle Muscular Dystrophy in the DBA/2J versus MRL strain showed the MRL background supported greater myofiber regeneration with reduced structural degradation of muscle. Transcriptomic profiling of dystrophic muscle in the DBA/2J and MRL strains indicated strain-dependent expression of the extracellular matrix (ECM) and TGF-b signaling genes. To investigate the MRL ECM, cellular components were removed from dystrophic muscle sections to generate decellularized “myoscaffolds”. Decellularized myoscaffolds from dystrophic mice in the protective MRL strain had significantly less deposition of collagen and matrix-bound TGF-b1 and TGF-b3 throughout the matrix. Dystrophic myoscaffolds from the MRL background were enriched in myokines. C2C12 myoblasts were seeded onto decellularized matrices from Sgcg-/- MRL and Sgcg-/- DBA/2J matrices. Acellular myoscaffolds from the dystrophic MRL background induced myoblast differentiation and growth compared to dystrophic myoscaffolds from the DBA/2J matrices. These studies establish that the MRL background also generates its effect through a highly regenerative ECM, which is active even in muscular dystrophy.

2024-06-05 | GSE235368 | GEO

Mus musculus

Project description:Hepatic expression data between C57BL/6J and DBA/2J mice

| PRJNA118319 | ENA

Mus musculus

Project description:Expression profiling of F2 progenies from C57BL/6J x DBA/2J

| PRJNA117717 | ENA

Mus musculus

Project description:Comparative analysis of gene expression in A/J CB versus DBA/2J

| PRJNA96321 | ENA

Hippocampus proteome Mus musculus

Project description:To describe the protein profile in hippocampus, colon and ileum tissue’ changing after the old faeces transplants, we adopted a quantitative label free proteomics approach.

2021-09-09 | PXD016432 | Pride

Decreased mRNA expression of malonyl-CoA decarboxylase emerges from an inborn error-like defect in the Mlycd gene of DBA/2J mice

Project description:Mlycd encodes malonyl-CoA decarboxylase (MCD), which is an enzyme that localizes in the cytosolic, mitochondrial, and peroxisomal compartments and catalyzes the conversion of malonyl-CoA into acetyl-CoA. Malonyl-CoA can be converted into malonylcarnitine (C3DC). Patients with an autosomal recessive defect of MCD and MCD KO mice have pronounced elevations of C3DC. Analysis of plasma C3DC levels in the BxD genetic reference population revealed increased levels in BxD strains that harbor the DBA/2J haplotype at the site of the Mlycd gene. RNA sequencing was performed on two samples of DBA/2J mouse livers and two C57BL/6J mouse livers. Decreased expression of Mlycd gene as well as intronic reads in intron 2 were observed in DBA/2J livers. Long-read sequecing of DBA/2J livers in the Mlycd region confirmed an intracisternal A-particle (IAP) retrotransposon in intron 2 of the DBA/2J Mlycd sequence. To confirm the causal nature of the variant, DBA/2J mice with and without the C57BL/6J variant of Mlycd spliced in were tested for products of MCD enzymatic activity, and the C57BL/6J variant was able to rescue the phenotype seen in the DBA/2J mice.

2024-10-26 | GSE186973 | GEO

Mus musculus

Project description:Comparative analysis of gene expression in C57BL/6J and DBA/2J aging lungs.

| PRJNA98903 | ENA