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Type 1 interferon signaling is crucial from the loss of tolerance nd the development of autoreactive B cells.

ABSTRACT: Type 1 interferon signaling is crucial from the loss of tolerance nd the development of autoreactive B cells.

PROVIDER: PRJNA474672 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7263390_1.fastq.gz	Fastqsanger.gz
	SRR7263390_2.fastq.gz	Fastqsanger.gz
	SRR7263391_1.fastq.gz	Fastqsanger.gz
	SRR7263391_2.fastq.gz	Fastqsanger.gz
	SRR7263382_1.fastq.gz	Fastqsanger.gz

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Type 1 interferon signaling is crucial from the loss of tolerance nd the development of autoreactive B cells.

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Project description:Regulatory T (Treg) cells are crucial for maintaining peripheral immune tolerance and preventing destructive autoreactive responses, but how heterogeneous Treg populations establish tolerant status remains unclear. Here, we found that Zinc finger protein 335 (Zfp335) is indispensable for the differentiation and maintenance of effector Treg (eTreg) population and immunological self-tolerance in neonates.Mice with Zfp335 deletion in Treg cells exhibit early-onset autoimmune disease with severe inflammation in multiple organs and unrestricted activation and expansion of conventional T cells.

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