Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Role of GATA in DN3 stage thymocytes

ABSTRACT: Role of GATA in DN3 stage thymocytes

PROVIDER: PRJNA475907 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7305545_1.fastq.gz	Fastqsanger.gz
	SRR7305545_2.fastq.gz	Fastqsanger.gz
	SRR7305546_1.fastq.gz	Fastqsanger.gz
	SRR7305546_2.fastq.gz	Fastqsanger.gz
	SRR7305547_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Role of GATA in DN3 stage thymocytes

Project description:RNA-seq in DN3 stage thymocytes isolated from wild type and Gata3 hypomorphic mutant mouse

2018-06-14 | GSE115739 | GEO

RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Project description:The NOTCH1-driven MYC enhancer (NMe) is essential for T cell development, transformation and the development of acute lymphoblastic leukemia. Here we analyze by RNAseq the gene expression profile of DN3 thymocytes from NMe wild type and NMe GATA site 1 and 2 (GS1+2) homozygous mutant mice. GSEA analysis show a significant enrichment of MYC signature genes, consistent with a deficient function of NMe in GATA site 1 and 2 homozygous mutant thymocytes.

2019-08-01 | GSE117483 | GEO

ATACseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Project description:The NOTCH1-driven MYC enhancer (NMe) is essential for T cell development, transformation and the development of acute lymphoblastic leukemia. Here we analyze chromatin accessibility by ATACseq in DN3 thymocytes and Notch-induced TALL blasts from NMe wild type and NMe GATA site 1 and 2 (GS1+2) homozygous mutant mice.

2019-08-01 | GSE117573 | GEO

Identification of the molecular targets of miR-185 in DN3 stage thymocytes

Project description:T cell-specific overexpression of miR-185 caused a developmental block at DN3 stage of thymopoiesis. DN3 stage thymocytes were sorted from the wild type (C57BL/6) and miR-185 Tg mice, followed by total RNA isolation.

2013-10-28 | E-GEOD-49057 | biostudies-arrayexpress

Role of Tcf-1 (Tcf7) in DN3 thymocytes

Project description:Comparison of wild-type and Tcf-1-deficient DN3 thymocytes

2021-11-01 | GSE93346 | GEO

Chromatin accessibility and transcriptomic profiling in NMe Gata-site double mutant mouse DN3 Thymocytes

Project description:Chromatin accessibility and transcriptomic profiling in NMe Gata-site double mutant mouse DN3 Thymocytes

| PRJNA482677 | ENA

Expression data from WT DN3, TCF-1-deficient DN3 thymocytes, and T cell lymphomas in TCF-1-deficient animals.

Project description:TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We used microarrays to detect gene expression changes in WT and TCF-1 deficient DN3 thymocytes as well as T cell lymphoma cells developed in TCF-1 KO mice. DN3 thymocytes were directly sorted from WT or TCF-1 KO mice. T cell lymphoma blast cells were also sorted from TCF-1 KO mice that developed the disease. RNA was extracted and hybridized to GeneChip Mouse GENE 1.0 ST arrays (Affymetrix).

2012-10-25 | E-GEOD-33292 | biostudies-arrayexpress

Identification of the molecular targets of miR-185 in DN3 stage thymocytes

Project description:T cell-specific overexpression of miR-185 caused a developmental block at DN3 stage of thymopoiesis.

2013-10-28 | GSE49057 | GEO

RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Project description:RNAseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

| PRJNA482314 | ENA

ATACseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

Project description:ATACseq in NMe wild type and NMe GATA site 1 and 2 homozygous mutant DN3 thymocytes

| PRJNA482545 | ENA