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Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression

ABSTRACT: Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression

PROVIDER: PRJNA478770 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7458504.fastq.gz	Fastqsanger.gz
	SRR7458505.fastq.gz	Fastqsanger.gz
	SRR7458506.fastq.gz	Fastqsanger.gz
	SRR7458507.fastq.gz	Fastqsanger.gz

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Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression

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Project description:BACKGROUND:Bacterial infections following childbirth-so-called puerperal infections-cause morbidity in 5%-10% of all new mothers. At low frequency, the infection can spread to the blood, resulting in life-threatening sepsis known as puerperal sepsis. Pathogens causing puerperal sepsis include group A Streptococcus (GAS), and epidemiological analyses have identified isolates of a single serotype, M28, as being nonrandomly associated with cases of puerperal sepsis. The genomes of serotype M28 GAS isolates harbor a 36.3-kb mobile genetic element of apparent group B Streptococcus origin, termed region of difference 2 (RD2). METHODS:The phenotypic (determined via tissue culture and a vaginal colonization model) and regulatory (determined via RNA sequencing analysis) contributions of RD2 were assessed by comparing parental, RD2 deletion mutant, and complemented mutant serotype M28 GAS strains. RESULTS:RD2 affords serotype M28 isolates an enhanced ability to adhere to human vaginal epithelial cells and to colonize the female reproductive tract in a mouse model of infection. In addition, RD2 influences the abundance of messenger RNAs from >100 core chromosomal GAS genes. CONCLUSIONS:The data are consistent with RD2 directly, via encoded virulence factors, and indirectly, via encoded regulatory proteins, modifying the virulence potential of GAS and contributing to the decades-old association of serotype M28 isolates with cases of puerperal sepsis.

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RD2-mediated regulation of gene expression following GAS exposure to human plasma

Project description:We used RNA-Seq to assess how the presence/absence of the RD2 pathogenicity island influences global gene expression in a serotype M28 GAS isolate following exposure to human plasma for 15 mins and for 60 mins

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