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Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression

ABSTRACT: Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression

PROVIDER: PRJNA478770 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7458504.fastq.gz	Fastqsanger.gz
	SRR7458505.fastq.gz	Fastqsanger.gz
	SRR7458506.fastq.gz	Fastqsanger.gz
	SRR7458507.fastq.gz	Fastqsanger.gz

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Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression

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Project description:BackgroundBacterial infections following childbirth-so-called puerperal infections-cause morbidity in 5%-10% of all new mothers. At low frequency, the infection can spread to the blood, resulting in life-threatening sepsis known as puerperal sepsis. Pathogens causing puerperal sepsis include group A Streptococcus (GAS), and epidemiological analyses have identified isolates of a single serotype, M28, as being nonrandomly associated with cases of puerperal sepsis. The genomes of serotype M28 GAS isolates harbor a 36.3-kb mobile genetic element of apparent group B Streptococcus origin, termed region of difference 2 (RD2).MethodsThe phenotypic (determined via tissue culture and a vaginal colonization model) and regulatory (determined via RNA sequencing analysis) contributions of RD2 were assessed by comparing parental, RD2 deletion mutant, and complemented mutant serotype M28 GAS strains.ResultsRD2 affords serotype M28 isolates an enhanced ability to adhere to human vaginal epithelial cells and to colonize the female reproductive tract in a mouse model of infection. In addition, RD2 influences the abundance of messenger RNAs from >100 core chromosomal GAS genes.ConclusionsThe data are consistent with RD2 directly, via encoded virulence factors, and indirectly, via encoded regulatory proteins, modifying the virulence potential of GAS and contributing to the decades-old association of serotype M28 isolates with cases of puerperal sepsis.

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RD2-mediated regulation of gene expression following GAS exposure to human plasma

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