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Expression data of circRNA from new diagnostic AML patients (with or without EMI) and healthy volunteers

ABSTRACT: Expression data of circRNA from new diagnostic AML patients (with or without EMI) and healthy volunteers

PROVIDER: PRJNA479516 | ENA |

REPOSITORIES: ENA

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Expression data of circRNA from new diagnostic AML patients (with or without EMI) and healthy volunteers

Project description:CircRNA microarray was conducted to further explore the underlying circRNA expression alterations in extramedullary infiltration (EMI) of AML. 4 matched samples from EMI, non-EMI AML patients and healthy volunteers were selected. Mononuclear cells from 12 bone marrow samples were separated according to protocols. RNA was then extracted and hybridization for further microarray analysis.

2018-07-04 | GSE116617 | GEO

Expression data of whole genome from new diagnostic AML patients (with or without EMI) and healthy volunteers

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Expression data of whole genome and circRNA from new diagnostic AML patients (with or without EMI) and healthy volunteers

Project description:Expression data of whole genome and circRNA from new diagnostic AML patients (with or without EMI) and healthy volunteers

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Expression data of whole genome and circRNA from new diagnostic AML patients (with or without EMI) and healthy volunteers

Project description:This SuperSeries is composed of the SubSeries listed below.

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RNA sequencing for AML patients with and without extramedullary infiltration

Project description:Extramedullary infiltration (EMI) is a concomitant manifestation indicating poor prognosis of acute myeloid leukemia (AML), yet the underlying mechanism remains poorly understood and therapeutic options are limited. Here, we employed single-cell RNA sequencing on bone marrow (BM) and EMI samples from an AML patient presenting pervasive leukemia cutis. A complement C1Q+ macrophage-like leukemia subset which is enriched within cutis and existed in BM prior to EMI manifestations was identified and further verified in multiple AML patients. RNA-sequencing and quantitative proteomics profiling revealed adverse prognosis of patients bearing C1Q+ population. C1Q expression endowed leukemia cells with tissue-infiltration ability which could establish prominent cutaneous or gastrointestinal EMI nodules in patient-derived xenograft (PDX) and CDX models. Fibroblasts attracted migration of the C1Q+ leukemia cells through surface C1Q-gC1QR recognition and subsequent stimulation of MAFB5 TGF-β signaling. Thus, C1Q orchestrates cancer infiltration pathways through communicating with fibroblasts and represents a compelling therapeutic target for EMI.

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Genotyping of human 459 diagnostic AML samples

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Transcriptome of GCKR-P446L-EMI-B6N on a high-fat high-sugar diet

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