Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hijacking of the macrophage epigenetic machinery involving H3K4 trimethylation and lncRNA HOTAIR, facilitates survival of Mycobacterium tuberculosis

ABSTRACT: Hijacking of the macrophage epigenetic machinery involving H3K4 trimethylation and lncRNA HOTAIR, facilitates survival of Mycobacterium tuberculosis

PROVIDER: PRJNA480205 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7497734.fastq.gz	Fastqsanger.gz
	SRR7497735.fastq.gz	Fastqsanger.gz
	SRR7497736.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Hijacking of the macrophage epigenetic machinery involving H3K4 trimethylation and lncRNA HOTAIR, facilitates survival of Mycobacterium tuberculosis

Project description:Genome wide differential association of H3K4me3 in Human macrophages after infection with both virulent and avirulent strains of Mtb

2018-07-10 | GSE116769 | GEO

H3K4 trimethylation ChIP - wild-type

Project description:Genome-wide location analysis of histone H3 lysine-4 trimethylation in wild-type strain Keywords: repeat

2006-12-01 | GSE4534 | GEO

H3K4 trimethylation ChIP - ctk1 deletion

Project description:Genome-wide location analysis of histone H3 lysine-4 trimethylation in a ctk1 deletion strain Keywords: repeat

2006-12-01 | GSE4533 | GEO

HOTAIR transfected Breast Cancer Cells

Project description:MDA-MB-231 Breast Cancer Cells were infected by retroviral expression with either VECTOR or HOTAIR. To test the role of polycomb in HOTAIR mediated gene expression, MDA-MB-231 HOTAIR cells were infected with short hairpin retroviral vectors targeting SUZ12 or EZH2. A genetic modification design type is where an organism(s) has had genetic material removed, rearranged, mutagenized or added, such as knock out. genetic_modification_design

2010-04-15 | E-GEOD-20435 | biostudies-arrayexpress

ChIRP-MS of long non-coding RNA HOTAIR

Project description:Accumulating evidence highlights the role of long non-coding RNAs (lncRNA) in cellular homeostasis, and their dysregulation in disease settings. Most lncRNAs function by interacting with proteins or protein complexes. While several orthogonal methods have been developed to identify these proteins, each method has its inherent strengths and limitations. Here, we combine two RNA-centric methods ChIRP-MS and RNA-BioID to obtain a comprehensive list of proteins that interact with the well-known lncRNA HOTAIR. Overexpression of HOTAIR has been associated with a metastasis-promoting phenotype in various cancers. Although HOTAIR is known to bind with PRC2 and LSD1 protein complexes, an unbiased and comprehensive method to map its interactome has not yet been performed. Both ChIRP-MS and RNA-BioID data sets show an association of HOTAIR with mitoribosomes, suggesting HOTAIR has functions independent of its (post-)transcriptional mode-of-action.

2022-02-15 | PXD029057 | Pride

HOTAIR transfected Breast Cancer Cells

2010-04-15 | GSE20435 | GEO

Role of Lsd1 in HOTAIR function

Project description:HOTAIR is a scafold long non-coding RNA tethering PRC2 and Lsd1/REST/coREST complexes to gene promoters to repress transcription of genes involved in epithelial to mesenchymal transition (EMT). To decipher a role of the Lsd1 in HOTAIR function we generated epithelial cell lines expressing full length and truncated versions of HOTAIR missing first 5'-300 (Epi-HOTΔP) and last 3'-500 bp (Epi-HOTΔL) interacting with HOTAIR partners. These cell lines were further used to determine Lsd1 binding sites using chromatin immunoprecipitation approach.

2021-04-22 | GSE106262 | GEO

Effects of HOTAIR RNAi on Transcriptomes in H23 Cells

Project description:We profiled transcriptomes in human lung cancer cell line H23 when the expression of HOTAIR was knockdown by the siRNA specific to an HOTAIR isoform HOTAIR-N (NR_047517).

2018-09-06 | GSE119510 | GEO

Effects of HOTAIR RNAi on Transcriptomes in T47D Cells

Project description:We profiled transcriptomes in human breast cancer cell line T47D when the expression of HOTAIR was knockdown by the siRNA specific to an HOTAIR isoform HOTAIR-N (NR_047517).

2018-09-06 | GSE119511 | GEO

Targeting H3K4 trimethylation in Huntington disease.

Project description:Transcriptional dysregulation is an early feature of Huntington disease (HD). We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a chromatin signature for this mark. Reducing the levels of the H3K4 demethylase SMCX/Jarid1c in primary neurons reversed down-regulation of key neuronal genes caused by mutant Huntingtin expression. Finally, reduction of SMCX/Jarid1c in primary neurons from BACHD mice or the single Jarid1 in a Drosophila HD model was protective. Therefore, targeting this epigenetic signature may be an effective strategy to ameliorate the consequences of HD.

| S-EPMC3740882 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data