Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Plasma exosomal miRNAs microarray in polymicrobial sepsis

ABSTRACT: Plasma exosomal miRNAs microarray in polymicrobial sepsis

PROVIDER: PRJNA480304 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Plasma exosomal miRNAs microarray in polymicrobial sepsis

Project description:Exosomal RNA isolated from plasma was successfully profiled with a total of 65 immunology-related miNRAs in 13 mouse samples

2018-07-10 | GSE116829 | GEO

Polymicrobial sepsis-induced Myocardial Depression Transcriptional Profile

Project description:To describe the transcriptional changes associated with polymicrobial-sepsis induced myocardial depression in wild type and iNOS deficient mice. Keywords: myocardium, contractility, differential gene expression, nitric oxide synthase, infection We compared the transcriptional profile of C57/BL6 WT mice and congenic B6 129P2-Nos2tm1Lau/J mice after 48 hrs of polymicrobial sepsis induced by caecal ligation and perforation. 48 hours after surgery, mice were anaesthetised (intraperitoneal 100 mg/kg ketamine and 10 mg/kg xylazine). The right common carotid artery was cannulated (Millar Mikro-Tip pressure transducing catheter: 1.4F sensor, 2F catheter; Houston TX). Pressure tracings from the aorta and left ventricle were recorded (SonoLAB software; Sonometrics Corp., London Ontario Canada) and analysed using Cardiosoft and Origin 6.0 (Sonometrics Corp., and Microcal Software, Northampton MA). The heart was removed, emptied of blood, and snap frozen.

2010-11-17 | E-GEOD-9667 | biostudies-arrayexpress

Plasma circulating miRNA profiling in polymicrobial sepsis by high throughput sequencing

Project description:Plasma circulating miRNA profiling in polymicrobial sepsis by high throughput sequencing

| PRJNA552351 | ENA

Polymicrobial sepsis-induced Myocardial Depression Transcriptional Profile

2010-11-17 | GSE9667 | GEO

The role of ferritin heavy chain (Fth) in polymicrobial sepsis.

Project description:We systematically assessed the transcriptomic changes of livers of MxCreFthD/D vs. Fthlox/lox mice after induction of polymicrobial sepsis using Cecal Ligation and Puncture. Data indicates a distinct set of genes differentially regulated between MxCreFthD/D and Fthlox/lox mice after sepsis induction reflecting altered iron and glucose metabolism.

2017-08-15 | GSE92703 | GEO

Plasma circulating miRNA profiling in polymicrobial sepsis by high throughput sequencing

Project description:Aim: To explore the potentially important role of circulating miRNAs in systemic inflammation during sepsis. Method: 8 to 10-week old C57BL/6 mice underwent cecal ligation and puncture (CLP) or laparotomy (Sham). Plasma RNA was isolated using Trizol LS reagent 24h post-surgery. NGS cDNA libraries were prepared using Norgen Biotek Small RNA Library Prep Kit. Library quality was validated prior to sequencing on an Illumina NextSeq 500 platform.

2020-04-12 | GSE133733 | GEO

Expression data of exosomal miRNAs extracted from plasma [Affymetrix miRNA 4.0]

Project description:Tuberculosis (TB) is difficult to diagnose under complex clinical conditions. Exosomal miRNAs have emerged as promising disease biomarkers. We aim to investigate the potential of exosomal miRNAs to assist with TB clinical diagnosis. In the present research, we used the Affymetrix Genechip miRNA 4.0 Array to investgate the profiles of differentially expressed miRNAs (DEMs) in the exosomes of peripheral blood plasma. As a result, exosomal miRNA profiling yielded a total of 102 DEMs (98 with up-expression and 4 with down-expression) between the TB (pulmonary tuberculosis and tuberculosis meningitis) patients and controls.

2018-07-03 | GSE116542 | GEO

Innate response activator B cells are sentinels that guard against polymicrobial sepsis

Project description:Innate immunity is fundamental to recognition and clearance of bacterial infection. The relevant cells and molecules that orchestrate an effective response, however, remain incompletely understood. Here we describe a previously unknown population of B cells, which we have named innate response activator (IRA) B cells that recognize bacteria directly through TLR-4-MyD88 and protect against polymicrobial sepsis. IRA-B cells have a unique IgM high CD23 low CD43 + CD93+ GM-CSF+ signature, develop and diverge from B1a B cells, require BAFFR, and adhere to tissue via VLA-4 and LFA-1. B cell subsets are sorted from the spleen and peritoneum of C57BL/6 mice that were given intraperitoneal injections of LPS once daily for four days.

2012-02-07 | E-GEOD-32372 | biostudies-arrayexpress

Diagnostic value of a panel of plasma exosomal miRNAs as potential biomarkers for thyroid nodules

Project description:Exosomes and exosomal miRNAs from the plasma of volunteers were isolated from thyroid nodules and papillary tyriod cancer patients . Profiling of exosomal miRNA was performed using next-generation sequencing(NGS) to identify miRNA candidates for diagnosis.

2019-05-01 | GSE130512 | GEO

Transcriptomic Profiling of Immune Cells in Murine Polymicrobial Sepsis

Project description:Transcriptomic Profiling of Immune Cells in Murine Polymicrobial Sepsis

| PRJNA1051532 | ENA