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Expression data from OVA-induced allergic mice

ABSTRACT: Expression data from OVA-induced allergic mice

PROVIDER: PRJNA483728 | ENA |

REPOSITORIES: ENA

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Expression data from OVA-induced allergic mice [Agilent]

Project description:Expression data from OVA-induced allergic mice [Agilent]

| PRJNA483731 | ENA

Expression data from OVA-induced allergic mice [Affymetrix]

Project description:Expression data from OVA-induced allergic mice [Affymetrix]

| PRJNA483732 | ENA

MeRIP Sequencing of Lung Tissues from OVA‐induced Acute Allergic Asthma Mice

Project description:The objective of the study was to present a transcriptome-wide m6A methylome profile of lung tissues in mouse model of ovalbumin(OVA)-induced acute allergic asthma.

2021-10-11 | GSE179874 | GEO

MeRIP Sequencing of Lung Tissues from OVA‐induced Acute Allergic Asthma Mice

Project description:MeRIP Sequencing of Lung Tissues from OVA‐induced Acute Allergic Asthma Mice

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Airborne particulate matter from goat farm increases acute allergic airway responses in mice increases acute allergic airway responses in mice

Project description:Background: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responses Methods: Fine (< 2.5 μm) BioPM was collected from an indoor goat stable. Female BALB/c mice were ovalbumin (OVA) sensitized and challenged with OVA or saline as control. The OVA and saline groups were divided in sub-groups and exposed intranasally to different concentrations (0, 0.9, 3, or 9 μg) of goat farm BioPM. Bronchoalveolar lavage fluid (BALF), blood and lung tissues were collected. Results: In saline-challenged mice, goat farm BioPM alone induced a dose-dependent increase in neutrophils in BALF and induced production of macrophage inflammatory protein-3a). In OVA-challenged mice, BioPM significantly enhanced 1) inflammatory cells in BALF, 2) OVA-specific Immunoglobulin (Ig)G1, 3) interleukin-23 production, 4) airway mucus secretion-specific gene expression. RNAseq analysis of lungs indicates that neutrophil chemotaxis and oxidation-reduction processes were the representative genomic pathways in saline and OVA-challenged mice, respectively. Conclusions: A single exposure to goat farm BioPM enhanced airway inflammation in both saline and OVA-challenged allergic mice, with neutrophilic response as Th17 disorder and eosinophilic response as Th2 disorder indicative of the severity of allergic responses. Identification of the mode of action by which farm PM interacts with airway allergic pathways will be useful to design potential therapeutic approaches.

2020-08-01 | GSE148240 | GEO

The differential expressed mRNAs in spleen B cells between control(normal)，PBS treated or SJMHE1(Schistosoma japonicum-derived peptide) treated OVA-induced allergic rhinitis mice.

Project description:In order to explore the molecular mechanism of SJMHE1 intervention in allergic rhinitis, an OVA-induced allergic rhinitis model was established and intervened by subcutaneous injection of PBS and SJMHE1. Then a global RNA sequencing of mouse spleen B cells from the control, PBS, and SJMHE1 groups were performed.

2023-04-30 | GSE229347 | GEO

Expression and MeDIP microarray data from IL13-induced allergic airway inflammation of mice lungs

Project description:This SuperSeries is composed of the following subset Series: GSE35979: Gene expression data from IL13-induced allergic airway inflammation of mice lungs GSE35980: MicroRNA expression data from IL13-induced allergic airway inflammation of mice lungs GSE37079: Methylated DNA immunoprecipitation (MeDIP) microarray data from IL13-induced allergic airway inflammation of mouse lungs Refer to individual Series

2012-04-06 | E-GEOD-37085 | biostudies-arrayexpress

Expression data from OVA-induced allergic mice [Agilent]

Project description:IgE antibodies are key mediators of food allergy, and the production of IgE is tightly regulated at the moleculaer and cellular level in the germinal center of lymph glands where specific sets of genes are up-regulated. We used microarrays to detail the global programme of gene expression underlying ovalbumin-induced allergy and identified distinct classes of up-regulated genes during this process.

2018-08-01 | GSE117900 | GEO

Expression data from OVA-induced allergic mice [Affymetrix]

2018-08-01 | GSE117898 | GEO

Expression data from ovalbumin (OVA) induced asthma model

Project description:Expression data from ovalbumin (OVA) induced asthma model

| PRJNA808964 | ENA