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Erythro-myeloid progenitors contribute endothelial cells to developing blood vessels

ABSTRACT: Erythro-myeloid progenitors contribute endothelial cells to developing blood vessels

PROVIDER: PRJNA483887 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7632520.fastq.gz	Fastqsanger.gz
	SRR7632530.fastq.gz	Fastqsanger.gz
	SRR7632521.fastq.gz	Fastqsanger.gz
	SRR7632522.fastq.gz	Fastqsanger.gz
	SRR7632523.fastq.gz	Fastqsanger.gz

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Erythro-myeloid progenitors contribute endothelial cells to developing blood vessels

Project description:The earliest blood vessels in the mammalian embryo are formed when endothelial cells (ECs) differentiate from angioblasts and coalesce into tubular networks. Thereafter, the en-dothelium is thought to expand solely by proliferation of pre-existing ECs. Here we show that the earliest precursors of erythrocytes, megakaryocytes and macrophages, the yolk sac-derived erythro-myeloid progenitors (EMPs), provide a complementary source of ECs that are recruited into pre-existing vasculature. Whereas a first wave of yolk sac-resident EMPs contributes ECs to the yolk sac endothelium, a second wave of EMPs colonises the embryo and contributes ECs to intraembryonic endothelium in multiple organs, where they persist into adulthood. By demonstrating that EMPs constitute a hitherto unrecognised source of ECs, we reveal that embryonic blood vascular endothelium expands in a dual mechanism that involves both the proliferation of pre-existing ECs and the incorporation of ECs derived from hematopoietic precursors.

2018-08-02 | GSE117978 | GEO

Erythro-myeloid progenitors contribute endothelial cells to blood vessels.

Project description:The earliest blood vessels in mammalian embryos are formed when endothelial cells differentiate from angioblasts and coalesce into tubular networks. Thereafter, the endothelium is thought to expand solely by proliferation of pre-existing endothelial cells. Here we show that a complementary source of endothelial cells is recruited into pre-existing vasculature after differentiation from the earliest precursors of erythrocytes, megakaryocytes and macrophages, the erythro-myeloid progenitors (EMPs) that are born in the yolk sac. A first wave of EMPs contributes endothelial cells to the yolk sac endothelium, and a second wave of EMPs colonizes the embryo and contributes endothelial cells to intraembryonic endothelium in multiple organs, where they persist into adulthood. By demonstrating that EMPs constitute a hitherto unrecognized source of endothelial cells, we reveal that embryonic blood vascular endothelium expands in a dual mechanism that involves both the proliferation of pre-existing endothelial cells and the incorporation of endothelial cells derived from haematopoietic precursors.

| S-EPMC6289247 | biostudies-literature

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

| PRJNA487779 | ENA

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

| PRJNA487777 | ENA

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

| PRJNA487781 | ENA

Identification of fibroblast progenitors in the developing thymus

Project description:Identification of fibroblast progenitors in the developing thymus

| PRJEB50163 | ENA

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors [ATAC-seq]

Project description:Yolk sac (YS) hematopoiesis is critical for the survival of the embryo and a major source of tissue-resident macrophages that persist into adulthood. Here we report that the epigenetic regulator Ezh2 is essential for YS hematopoiesis but dispensable for subsequent aorta–gonad–mesonephros (AGM) blood development. Loss of Ezh2 activity in hemogenic endothelium (HE) leads to the generation of phenotypically intact but functionally deficient erythro-myeloid progenitors (EMP). Ezh2 activity is critical at the onset of the endothelial-to-hematopoietic transition generating EMPs but rapidly dispensable after that. We identified a lack of downregulation of Wnt signaling as the primary reason in the generation of non-functional EMPs. Together, our findings demonstrate a critical and specific role of Ezh2 in modulating Wnt signaling during the generation of EMPs from YS HE.

2021-06-01 | GSE150292 | GEO

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors [RNA-seq]

2021-08-16 | GSE150032 | GEO

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.

Project description:Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.

| PRJNA753778 | ENA

Bentonite clay pressure vessels

Project description:Bentonite clay pressure vessels

| PRJEB39478 | ENA