Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of ORY-2001, ORY-LSD1, FTY720 on gene expression in EAE mice.

ABSTRACT: Effect of ORY-2001, ORY-LSD1, FTY720 on gene expression in EAE mice.

PROVIDER: PRJNA484325 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Effect of ORY-2001, ORY-LSD1, FTY720 on gene expression in EAE mice.

Project description:Gene expression analysis in the spinal cord and brain of vehicle-treated and ORY-2001 and ORY-LSD1 treated EAE mice in the subchronic (SC) and of ORY-2001 and ORY-LSD1 in the effector (E) phase in EAE mice

2021-08-03 | GSE118071 | GEO

Effect of ORY-2001 on hippocampus and prefrontal cortex of SAMP8 mice.

Project description:Gene expression analysis in the hippocampus and prefrontal cortex of vehicle-treated and ORY-2001 treated SAM mice.

2020-05-13 | GSE100413 | GEO

Effects of FTY720 on B cells in experimental autoimmune encephalomyelitis (EAE)

Project description:MP4-induced experimental autoimmune encephalomyelitis (EAE) is a B cell-dependent mouse model of multiple sclerosis (MS), which enables targeted research on B cells, currently much discussed protagonists in MS pathogenesis. Here, we used this model to study the impact of the S1P1 receptor modulator FTY720 (fingolimod) on the autoreactive B cell and antibody response both in the periphery and central nervous system (CNS) itself.

2020-02-07 | GSE94636 | GEO

Effect of Clostridia strains on EAE clinical outcome as a therapeutic treatment

Project description:Researchers have induced an experimental model of multiple sclerosis [experimental autoimmune encephalomyelitis (EAE)] in mice to investigate the therapeutic effect of the oral treatment with selected Clostridia strains on the clinical outcome of EAE and its mechanisms of action

2021-09-15 | GSE155438 | GEO

Effect of needling treatments on GB20 acupoint in EAE model mice

Project description:Purpose: We used RNA sequencing to investigate the effect of needling treatments on GB20 acupoint in EAE model mice Methods: Retinal mRNA profiles of 13-week-old female sham control mice (SHAM), EAE model mice with MOG injection (MOG), EAE model mice with needling treatment at acupoint GB20 (GB20) and its control acupoint GV16 (GV16) were generated by deep sequencing, in triplicate, using Illumina Hiseq platform. The sequence reads that passed quality filters were analyzed with DESeq2 R package to identify differently expressed genes with padj<0.05. Results: RNA-seq identified total 234 DEGs, with 100 genes upregulated and 134 genes downregulated, comparing MOG group with SHAM group.Further analysis revealed that, among the MOG injection induced 100 up-regulated DEGs, 24 DEGs were reversed and significantly down-regulated by GB20 treatment, while 14 were reversed and significantly down-regulated by GV16 treatment. However, 12 of the 14 reversed DEGs of GV16 treatment were already included in the 24 DEGs of GB20. The left 2 DEGs specific to GV16 treatment were Gfap (glial fibrillary acidic protein) and Fgf2 (fibroblast growth factor 2). As to the MOG injection induced 134 down-regulated DEGs, 12 DEGs were reversed and significantly up-regulated by GB20 treatment, while only 3 DEGs were reversed and significantly up-regulated by GV16 control treatment, and all the 3 DEGs were included in the 12 DEGs of GB20 treatment. Conclusions: Our research first reported that needling treatment on GB20 had regulation effects on retinal transcriptome of EAE model mice, indicating potential way of therapy for treatment of optic neuritis.

2020-10-27 | GSE148759 | GEO

Effect of needling treatments on GB20 acupoint in EAE model mice

Project description:Effect of needling treatments on GB20 acupoint in EAE model mice

| PRJNA625656 | ENA

Spinal cord gene expression profiling of the effect of EHP-101 in EAE model

Project description:Spinal cord gene expression profiling of the effect of EHP-101 in EAE model

2020-06-21 | GSE131854 | GEO

Stool proteome of EAE mice prior to physical symtoms but after immunization

Project description:TMT-labeled shotgun proteomics of mouse stool collected before and after EAE immununization.

2019-11-13 | PXD012287 | Pride

Panicum virgatum cultivar:2001

Project description:Panicum virgatum exome capture - 2001

| PRJNA446794 | ENA

Analysis of serum cytokine levels of EAE mice

Project description:Sera of experimental autoimmune encephalomyelitis (EAE) or control mice were collected at day 18 post immunization. Comprehensive analysis of cytokine levels were performed by using commercially available RayBio Mouse Cytokine Array 2 (RayBiotech, Inc.) according to manufacturer’s protocol 4 samples.There are two groups: vehicle control group and EAE group. Each group consists of 2 replications.

2013-05-31 | E-GEOD-47499 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data