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Stool proteome of EAE mice prior to physical symtoms but after immunization

ABSTRACT: TMT-labeled shotgun proteomics of mouse stool collected before and after EAE immununization.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

DISEASE(S): Autoimmune Disease Of Central Nervous System

SUBMITTER: Carlos Gonzalez

LAB HEAD: Joshua Elias

PROVIDER: PXD012287 | Pride | 2019-11-13

REPOSITORIES: pride

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Dataset's files

Source:

			Action	DRS
	Control_run_PeptideGroups.txt	Txt
	Control_run_Proteins.txt	Txt
	FL0008791.raw	Raw
	FL0008791_M3.xlsx	Xlsx
	FL0008791_M3_peptide.xlsx	Xlsx

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Publications

Latent-period stool proteomic assay of multiple sclerosis model indicates protective capacity of host-expressed protease inhibitors.

Gonzalez Carlos G CG Tankou Stephanie K SK Cox Laura M LM Casavant Ellen P EP Weiner Howard L HL Elias Joshua E JE

Scientific reports 20190828 1

Diseases are often diagnosed once overt symptoms arise, ignoring the prior latent period when effective prevention may be possible. Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, exhibits such disease latency, but the molecular processes underlying this asymptomatic period remain poorly characterized. Gut microbes also influence EAE severity, yet their impact on the latent period remains unknown. Here, we show the latent period between immunization and EAE's ove ...[more]

PMID: 31462662

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