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ABSTRACT: RNA-Seq of Heligmosomoides polygyrus under varying mice gut condition

PROVIDER: PRJNA486010 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7693871_1.fastq.gz	Fastqsanger.gz
	SRR7693871_2.fastq.gz	Fastqsanger.gz
	SRR7693872_1.fastq.gz	Fastqsanger.gz
	SRR7693872_2.fastq.gz	Fastqsanger.gz
	SRR7693873_1.fastq.gz	Fastqsanger.gz

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1 - 5 of 12

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Project description:Heligmosomoides polygyrus RNA sequencing

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microarray analysis of bone marrow derived macrophages stimulated with helminth larvae and immune serum

Project description:Mouse bone marrow derived macrophages were stimulated with L3 larvae of the helminth Heligmosomoides polygyrus (Hp) (500 L3 /1 mio cells) in the presence or absence of immune serum (1:50 v:v) from challenge-Hp-infected mice.

2013-12-31 | E-MEXP-3920 | biostudies-arrayexpress

Heligmosomoides polygyrus

Project description:Heligmosomoides polygyrus overview

| PRJNA301368 | ENA

Parasitic helminths repress the canonical intestinal stem cell program

Project description:The intestinal helminth parasite Heligmosomoides polygyrus initiates infection in mice by penetrating the duodenal mucosa, where it develops while surrounded by a multicellular granulomatous infiltrate before emerging into the intestinal lumen. We examined early H. polygyrus infection to assess the epithelial response to disruption of the mucosal barrier. Unexpectedly, intestinal stem cell markers, including Lgr5 and Olfm4, were completely lost in crypts overlying larvae-associated granulomas. We sought to identify the mechanism by which the H. polygyrus granuloma represses the activity of intestinal stem cells.

2018-04-12 | GSE97405 | GEO

RNAseq of murine small intestinal organoid cultures treated with Type 1 (IFNg) or Type 2 (IL4+IL13) cytokines in the presence or absence of excretory/secretory (ES) products of the helminth parasite Heligmosomoides polygyrus

Project description:Heligmosomoides polygyrus is a natural intestinal parasite of mice which exerts wide ranging modulatory effects on the immune system. This experiment was designed to investigate its abillity to modify intestinal epithelial cells, which form part of its natural niche. We tested gene expression in vitro, in differentiating organoids of small intestinal origin, exposed to cytokines and the released products of the parasite, termed HpES.

2021-11-12 | E-MTAB-11118 | biostudies-arrayexpress

The effects of abundant nematode-derived miRNAs on the transcriptome of mouse differentiating Th2 cells

Project description:Four microRNAs(miRNAs) highly abundantly secreted by the parasitic nematode Heligmosomoides polygyrus were synthesized (miRVana, Ambion) and transfected repeatedly into differentiating Th2 cells in vitro, individually or in combination. The effects of the different transfection regimens were assessed by RNA sequencing (Illumina).

2022-06-07 | GSE180829 | GEO

ngHelPoly2

Project description:Heligmosomoides polygyrus genome assembly, ngHelPoly2

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ngHelPoly1

Project description:Heligmosomoides polygyrus genome assembly, ngHelPoly1

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Exosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system [Litomosoides sigmodontis]

Project description:In mammalian systems, extracellular small RNAs can operate in a paracrine manner to communicate information between cells, relying on transport within vesicles. “Foreign” small RNAs derived from bacteria, plants and parasites have also been detected in mammalian body fluids, sparking interest in whether these could mediate inter-species communication. However, there is no mechanistic framework for RNA-mediated interspecies communication and the active movement of RNA via vesicles has not been shown outside of mammals. Here we demonstrate that specific microRNAs and Y RNAs are packaged into vesicles secreted by a gastrointestinal nematode, Heligmosomoides polygyrus, which naturally infects mice. Total RNA was extracted from the serum of mice infected with Litomosoides sigmodontis at 60 days post infection

2014-11-26 | E-GEOD-60021 | biostudies-arrayexpress

The production of Excretory-Secretory molecules from Heligmosomoides polygyrus bakeri fourth stage larvae varies between mixed and single sex cultures.

Project description:In this study, the composition of ES of male and female L4 stage Heligmosomoides polygyrus bakeri in the presence (cultured together) or absence (cultured alone) of the opposite sex was examined using mass spectrometry.

2021-09-10 | PXD023759 | Pride

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