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Epigenome analysis of cohorts infants and toddlers: children raised in orphanages and children raised in biological families

ABSTRACT: Epigenome analysis of cohorts infants and toddlers: children raised in orphanages and children raised in biological families

PROVIDER: PRJNA487365 | ENA |

REPOSITORIES: ENA

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Epigenome analysis of cohorts infants and toddlers: children raised in orphanages and children raised in biological families

Project description:Genome wide DNA methylation profiling of whole blood cells. The the Illumina Infinium MethylationEPIC microarray was used. Two children's cohorts were studied: 29 children residing in the orphanages (institutional care group, IC) and 29 children being raised in biological families (biological family care group, BFC)

2019-01-21 | GSE118940 | GEO

Upper airway proteomes of infants and children in sub-Saharan Africa

Project description:Mass spectrometry-based proteomics was carried out on Naso- and oropharyngeal swabs collected from infants and children presenting to hospital with both mild and severe respiratory illnesses as well as age-matched control children who were well and sampled from home.

2018-04-04 | MSV000082238 | MassIVE

Defective viral genomes determine respiratory syncytial virus disease severity in adult and children cohorts

Project description:Defective viral genomes determine respiratory syncytial virus disease severity in adult and children cohorts

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NIH RECOVER-Pediatric: Understanding the long-term impact of COVID on children and families

Project description:NIH RECOVER-Pediatric: Understanding the long-term impact of COVID on children and families

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Comparison of Transcriptome-wide N6-methyladenosine profiles from healthy trio families reveals regulator-mediated methylation alterations.

Project description:By performing methylated RNA immunoprecipitation sequencing (MeRIP-seq) to profile a transcriptome-wide N6-methyladenine modification in lymphoblastoid cell lines (LCLs) of 18 individuals from 6 YRI families. We found that that more than 70% of m6A peaks are shared by children and their parents, but the difference between patients and children is higher than that between families. The group-specific peaks in children are primarily enriched in cell cycle control, while those in parents are mainly enriched in chromatin/histone modifications. Moreover, the protein-protein interaction(PPI) network showed that seven significantly m6A regulators were closely interact with age-related genes, APOE and CEBPA, . In addition, we found that more SNPs are enriched around m6A peaks, and both parents-derived SNVs and de novo mutations could contribute to m6A methylation levels.

2023-11-18 | GSE222420 | GEO

Proteomic analysis of protein profile of blood serum of patients with autism children

Project description:A comparative panoramic mass spectrometric analysis of serum samples from three families with children with autistic disorders was carried out. The total number of examined samples was nine, including four control samples from healthy parents, and five samples from autistic children.

2016-11-01 | PXD005193 | Pride

Epigenetic profiling of children with respiratory allergy

Project description:The prevalence of respiratory allergy in children is increasing. Epigenetic changes (e.g. DNA methylation) are plausible underlying molecular mechanisms. Longitudinal birth cohorts are instrumental to study the relation between early-life environmental factors and the development of complex diseases. Our AXA Research Fund and Cefic-LRI supported project explores the hypothesis that chemical exposures during pregnancy can influence the immune system and development of allergy in children. Questionnaire data, as well as cord blood, plus blood and saliva samples at age 11 years, were collected in substudies of two longitudinal birth cohorts in Belgium (FLEHS1 & FLEHS2) and analyzed with Illumina Methylation 450K BeadChips as well as gene targeted iPLEX MassArrays analysis. The project aims to answer the following questions: 1) can we identify specific changes in epigenetic modifications on DNA from allergic compared to not-allergic children; 2) are these allergy-related epigenetic changes a result of chemical exposure during pregnancy; and 3) did the early life exposures leave an epigenetic “mark” that is maintained through childhood. If chemicals exposures and resulting predictive markers of allergic diseases can be detected early, prevention strategies, particularly in children or before pregnancy, could be developed.

2018-02-06 | GSE110128 | GEO

EPIPARK and HBS2 Cohorts

Project description:EPIPARK and HBS2 Cohorts

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EPIPARK and HBS2 Cohorts

Project description:EPIPARK and HBS2 Cohorts

| PRJNA691646 | ENA

Identification of protein biomarkers for pneumococcal meningitis in children C4PR_LIV

Project description:Bacterial meningitis is usually fatal without treatment. Prompt and accurate diagnosis coupled with the timely administration of parenteral antibiotics is necessary in order to save lives. We used label-free mass spectrometry based quantitative proteomics to identify specific protein signatures in cerebrospinal fluid from Malawian children with Streptococcus pneumoniae infection, the leading cause of bacterial meningitis in children, elderly and people infected with Human Immunodeficiency Virus. Samples were analysed in two independent cohorts (cases and controls, n=12 for the discovery cohort and n=16 for the verification cohort). The protein profiles clearly discriminated cases and controls. Proteins involved in the immune response and exosome cell signaling were significantly enriched in the infected samples. Several S. pneumoniae membrane proteins were identified suggesting these as potential therapeutic targets. For both cohorts, over 200 human proteins were up and down-regulated in children with confirmed S. pneumoniae infection in comparison with controls. Compiling proteins up- and down- regulated in both discovery and verification cohorts, we generated a comprehensive list of over 140 proteins from which diagnostic biomarkers could be nominated. For a panel of five selected proteins (cathelicidin, ceruloplasmin, myeloperoxidase, cystatin C and protein S100A8/S100 A9), we additionally verified the label-free results by automated quantitative western blot immunoassays (Simple Western™), with excellent agreement between the two experimental approaches. The proteins identified in our study could form the basis of development of a biomarker panel for rapid diagnosis. Our results could lead to the development of point-of-care assays to inform diagnosis, and to nominate new targets for drugs and vaccines to improve disease management and consequently to enhance the prognosis of children with bacterial meningitis.

2017-08-03 | PXD004219 | Pride

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