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Binding profile of the bZIP transcription factor, ATF-7, in C. elegans on pathogenic Pseudomonas aeruginosa

ABSTRACT: Binding profile of the bZIP transcription factor, ATF-7, in C. elegans on pathogenic Pseudomonas aeruginosa

PROVIDER: PRJNA488661 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7771410.fastq.gz	Fastqsanger.gz
	SRR7771420.fastq.gz	Fastqsanger.gz
	SRR7771411.fastq.gz	Fastqsanger.gz
	SRR7771421.fastq.gz	Fastqsanger.gz
	SRR7771412.fastq.gz	Fastqsanger.gz

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Binding profile of the bZIP transcription factor, ATF-7, in C. elegans on pathogenic Pseudomonas aeruginosa

Project description:ChIP-seq of ATF-7::GFP from Wild Type or pmk-1 mutant animals exposed to either non-pathogenic E. coli OP50 or pathogenic P. aeruginosa PA14

2019-02-01 | GSE119293 | GEO

Transcriptional profiling of C. elegans on pathogenic Pseudomonas aeruginosa

Project description:RNA-seq of Wild Type (N2), pmk-1 or atf-7 mutant animals exposed to either non-pathogenic E. coli OP50 or pathogenic P. aeruginosa PA14

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C. elegans on pathogenic Pseudomonas aeruginosa

Project description:C. elegans on pathogenic Pseudomonas aeruginosa

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Transcriptional profiling of C. elegans on pathogenic Pseudomonas aeruginosa

Project description:Transcriptional profiling of C. elegans on pathogenic Pseudomonas aeruginosa

| PRJNA488660 | ENA

C. elegans gene expression in response to the pathogenic P. aeruginosa strain PA14.

Project description:Analysis of differential gene expression in C. elegans adults exposed to three different bacteria: E. coli strain OP50, wild-type P. aeruginosa PA14 and gacA mutant PA14. Samples were analyzed at 4 hours and 8 hours after exposure to the different bacteria. These studies identified C. elegans genes induced by pathogen infection. Keywords: Time course, response to pathogen infection

2007-02-08 | GSE5793 | GEO

Response of C. elegans immune pathway mutants to P. aeruginosa infection

Project description:Synchronized C. elegans cultures of three geontypes -- wildype N2, daf-2(e1370) and sma-6(wk7) -- were prepared using standard techniques (http://cmgm.stanford.edu/~kimlab/index_methods.html). Live young adult worms were split between NG plates pre-seeded with the non-pathogenic E. coli strain OP50 or the Pseudomonas aeruginosa clinical isolate PA14 and incubated at 25C for 4 or 24 hours before harvesting. This experiment was repeated at least three times on independent occasions. cDNA probes were prepared from experimental samples and from reference mRNA extracted from mixed stage wild type worms grown at 25C, and were labeled with Cy3 or Cy5, as indicated. A reference experiement design type is where all samples are compared to a common reference. Elapsed Time: Time Infection: Exposure to the non-pathogenic E. coli strain OP50 or to the pathogenic Pseudomonas aeruginosa strain PA14 Strain Name: C. elegans wildtype strain N2 or the immune pathway mutants daf-2(e1370) or sma-6(wk7) Keywords: reference_design Computed

2008-11-05 | E-GEOD-13473 | biostudies-arrayexpress

Response of C. elegans immune pathway mutants to P. aeruginosa infection

2008-11-06 | GSE13473 | GEO

Identify genes regulated by zip-2 in absence and presence of P. aeruginosa PA14 infection at 4h

Project description:Very little is known about how animals discriminate pathogens from innocuous microbes. To address this question, we examined infection-response gene induction in the nematode Caenorhabditis elegans. We focused on genes that are induced in C. elegans by infection with the bacterial pathogen Pseudomonas aeruginosa, but are not induced by an isogenic attenuated gacA mutant. Most of these genes are induced independently of known immunity pathways. We generated a GFP reporter for one of these genes, infection response gene 1 (irg-1), which is induced strongly by wild-type P. aeruginosa strain PA14, but not by other C. elegans pathogens or by other wild-type P. aeruginosa strains that are weakly pathogenic to C. elegans. To identify components of the pathway that induces irg-1 in response to infection, we performed an RNA interference screen of C. elegans transcription factors. This screen identified zip-2, a bZIP transcription factor that is required for inducing irg-1, as well as several other genes, and is important for defense against infection by P. aeruginosa. These data indicate that zip-2 is part of a specialized pathogen response pathway that is induced by virulent strains of P. aeruginosa and provides defense against this pathogen. Analysis of differential gene expression in adult N2 C. elegans treated with L4440 control RNAi or zip-2 RNAi, either uninfected (feeding on E. coli) or infected with P. aeruginosa PA14; samples were analyzed after 4 hours of infection

2013-08-30 | E-GEOD-50513 | biostudies-arrayexpress

Identify genes regulated by zip-2 in absence and presence of P. aeruginosa PA14 infection at 4h

2013-08-30 | GSE50513 | GEO

Transcription profiling of C. elegans gene response to the pathogenic P. aeruginosa strain PA14.

Project description:Analysis of differential gene expression in C. elegans adults exposed to three different bacteria: E. coli strain OP50, wild-type P. aeruginosa PA14 and gacA mutant PA14. Samples were analyzed at 4 hours and 8 hours after exposure to the different bacteria. These studies identified C. elegans genes induced by pathogen infection. Experiment Overall Design: Three independent biological replicates were isolated for each treatment. All treatments were performed in parallel.

2008-06-14 | E-GEOD-5793 | biostudies-arrayexpress

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