Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Bergeyella cardium: Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis

PROVIDER: PRJNA490389 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR7820386_1.fastq.gz	Fastqsanger.gz
	SRR7820387_1.fastq.gz	Fastqsanger.gz
	SRR7820387_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Bergeyella cardium

Project description:Bergeyella cardium overview

| PRJNA972800 | ENA

Bergeyella cardium

Project description:Bergeyella cardium Genome sequencing and assembly

| PRJNA449612 | ENA

Bergeyella cardium strain:BCV

Project description:Bergeyella cardium strain:BCV Genome sequencing

| PRJNA909954 | ENA

Bergeyella cardium strain:BC

Project description:Bergeyella cardium strain:BC Genome sequencing

| PRJNA951281 | ENA

Pandoraea pnomenusa possible endocarditis

Project description:Possible prosthetic valve endocarditis by Pandoraea pnomenusa and specific virulence mechanisms

| PRJEB43050 | ENA

Loss of sterol demethylase activity reduces both azole and echinocandin antifungal susceptibility in a clinical isolate of C. parapsilosis

Project description:The present study describes a novel mechanism of antifungal resistance affecting the susceptibility of both the azole and echinocandin antifungals in an azole-resistant isolate from a matched pair of C. parapsilosis isolates obtained from a patient with prosthetic valve endocarditis. Transcriptome analysis indicated differential expression of several genes in the resistant isolate including upregulation of ERG1, ERG2, ERG5, ERG6, ERG11, ERG24, ERG25, ERG27, DAP1 and UPC2, of the ergosterol biosynthesis pathway. Whole genome sequencing revealed a mutation in the ERG3 gene leading to a G111R amino acid substitution in the resistant isolate. Subsequent introduction of this allele in the native ERG3 locus in the susceptible isolate resulted in a fluconazole MIC of >64 mg/ml and a caspofungin MIC of 8 mg/ml. Corresponding allelic replacement of the wildtype allele for the mutant allele in the resistant isolate resulted in a drop in MIC to 1 mg/ml for both fluconazole and caspofungin. Sterol profiles indicated a loss of sterol demethylase activity as a result of this mutation. This work demonstrate that this G111R mutation is wholly responsible for the resistant phenotype in the C. parapsilosis resistant isolate and is the first report of this multidrug resistance mechanism.

2017-05-25 | GSE98986 | GEO

Project description:Infectious native valve endocarditis by Streptococcus agalactiae species: Cases Report of pathogen identification only through metagenomic sequencing technology.

| PRJNA808198 | ENA

Finegoldia magna ATCC 29328

Project description:A causal agent of valve endocarditis

| PRJDA18981 | ENA

Protein components of infective endocarditis vegetations and insights on their proteolysis using mass spectrometry-based N-terminomics

Project description:Infective endocarditis results in the growth of a vegetative mass on native or bio prosthetic valves hindering function and increasing risk of thromboses. This study set out to determine the proteomic composition of these vegetations including the influence of different micro-organisms and the proteases known to be present. Our data has allowed us to describe for first time the influence different infectious organisms have on vegetation growth. Including the contribution of the immune response and circulatory proteins/cells make in composing a vegetation. Furthermore, we describe the protease activity and both known and novel cleavage sites in a plethora of targets. This data provides a deep insight into the homogeneity and heterogeneity of vegetation composition.

2020-07-29 | PXD019129 | Pride

Protein components of infective endocarditis vegetations and insights on their proteolysis using mass spectrometry-based N-terminomics

Project description:Infective endocarditis results in the growth of a vegetative mass on native or bio prosthetic valves hindering function and increasing risk of thromboses. This study set out to determine the proteomic composition of these vegetations including the influence of different micro-organisms and the proteases known to be present. Our data has allowed us to describe for first time the influence different infectious organisms have on vegetation growth. Including the contribution the immune response and circulatory proteins/cells make in composing a vegetation. Furthermore, we describe the protease activity and both known and novel cleavage sites in a plethora of targets. This data provides a deep insight into the homogeneity and heterogeneity of vegetation composition.

2020-07-29 | PXD016415 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data