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Artibeus jamaicensis, Mormoops megalophylla, Myotis keaysi, Nyctinomops laticaudatus and Peropteryx macrotis

ABSTRACT: De novo assembly and transcriptome functional annotation of liver from five tropical bat species

PROVIDER: PRJNA490553 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7910150_1.fastq.gz	Fastqsanger.gz
	SRR7910150_2.fastq.gz	Fastqsanger.gz
	SRR7910151_1.fastq.gz	Fastqsanger.gz
	SRR7910151_2.fastq.gz	Fastqsanger.gz
	SRR7910142_1.fastq.gz	Fastqsanger.gz

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Project description:Transcriptome Profiling of a Pathogenic Response to a Viral Infection in Jamaican Fruit Bats Artibeus jamaicensis Experimentally Infected With Tacaribe Virus

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Transcriptome Profiling of a Pathogenic Response to a Viral Infection in Jamaican Fruit Bats Artibeus jamaicensis Experimentally Infected With Tacaribe Virus

Project description:Bats are a widespread group of mammals thought to host a variety of viruses and other disease agents. Here we performed RNA-sequencing on Artibeus jamaicensis infected with the New World arenavirus, Tacaribe Virus, to generate an extensive bat transcriptome.

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Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis).

Project description:The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoronaviruses. Investigations into the origin of MERS-CoV have focused on two potential reservoirs: bats and camels. Here, we investigated the role of bats as a potential reservoir for MERS-CoV. In vitro, the MERS-CoV spike glycoprotein interacted with Jamaican fruit bat (Artibeus jamaicensis) dipeptidyl peptidase 4 (DPP4) receptor and MERS-CoV replicated efficiently in Jamaican fruit bat cells, suggesting there is no restriction at the receptor or cellular level for MERS-CoV. To shed light on the intrinsic host-virus relationship, we inoculated 10 Jamaican fruit bats with MERS-CoV. Although all bats showed evidence of infection, none of the bats showed clinical signs of disease. Virus shedding was detected in the respiratory and intestinal tract for up to 9 days. MERS-CoV replicated transiently in the respiratory and, to a lesser extent, the intestinal tracts and internal organs; with limited histopathological changes observed only in the lungs. Analysis of the innate gene expression in the lungs showed a moderate, transient induction of expression. Our results indicate that MERS-CoV maintains the ability to replicate in bats without clinical signs of disease, supporting the general hypothesis of bats as ancestral reservoirs for MERS-CoV.

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