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Effect of knockdown of S100A4 on gene expression in A549 cells

ABSTRACT: Effect of knockdown of S100A4 on gene expression in A549 cells

PROVIDER: PRJNA497892 | ENA |

REPOSITORIES: ENA

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Effect of knockdown of S100A4 on gene expression in A549 cells

Project description:S100A4 is a tumor metastasis-promoting protein and drives lung cancer cell invasion and its elevation level is associated with lymphovascular invasion and the decreased overall survival among lung cancer patients. However, how it alters cancer cell metabolism and how metabolic changes affect the invasive and metastatc capacity are unknown.

2019-03-15 | GSE121628 | GEO

Effect of ADGRF4 knockdown on gene expression pattern in A549 cells

Project description:Effect of ADGRF4 knockdown on gene expression pattern in A549 cells

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Differential gene expression profile of S100A4 null mouse lens

Project description:Whole lens transcriptome profiling by RNA-seq analysis was performed to investigate the role of S100A4 in lens architecture and function. These studies yielded the intriguing discovery that absence of S100A4 in the lens results in robust induction of gene expression of S100A5, an olfactory sensory neuron specific protein, and of genes encoding various photoreceptor and Müller glial cell proteins

2020-01-19 | GSE143909 | GEO

Secretome analysis of HSPD1 knockdown in A549 lung cancer cells

Project description:HSPD1 knockdown was established in A549 cells using an shRNA approach. Secretomes from both shHSPD1-A549 and shControl-A549 cells were collected and subjected to label-free comparative proteome analysis using SWATH-MS.

2024-04-13 | PXD050755 | Pride

Gene expression profiles of PML knockdown or WDR4 overexpression in A549 cells

Project description:Lung cancer cell line, A549 cells, was transfected with siPML or siCtrl for 48hr to knockdown PML expression. WDR4 or vector was overexpressed in A549 cells for 48hr. These four sets of cells were then subjected to microarray profiling using the Human OneArray microarray (version HOA6.1, GEO Platform GPL19137) from Phalanx Biotech Group. Comparison of transcriptomes from siPML/siCtrl and W4/vec in A549 cells

2016-07-04 | E-GEOD-83499 | biostudies-arrayexpress

Comparison of gene expression profiles between S100A4-positive and -negative cells isolated from the Peyer's patches

Project description:To identify gene products expressed in S100A4-producing cells in Peyer's patches, we used transgenic mice expressing enhanced green fluorescent protein (EGFP) under the control of the mouse S100A4 promoter (S100A4-GFP mice) and analyzed gene expression profiles using microarray. As a result, we found that S100A4-producing cells expressed many genes characteristic of LysoMac/DCs and ILC3s.

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Effect of TUC338 knockdown on gene expression

Project description:Effect of TUC338 knockdown on gene expression

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Effect of extracellular S100A4 on melanoma cells of different phenotypes

Project description:S100A4 is a known metastasis-promoting factor, rich in the tumor microenvironment. To clarify how extracellular S100A4 execute its pro-metastatic function, we analyzed gene expression in melanoma cells stimulated with recombinant protein rS100A4 and compared it to the expression in control non-stimulated cells. Two melanoma cell lines representing two distinct phenotypes M-bM-^@M-^S invasive (Melmet 1) and non-invasive/proliferative (Melmet 5) M-bM-^@M-^S were included in the study. The response at the gene expression level was much stronger in Melmet 5 than in Melmet 1. Melmet 5 down-regulated genes associated with melanocytic differentiation, indicating that Melmet 5 cells gained dedifferentiated, more invasive phenotype after stimulation with rS100A4. The observed changes in the expression of metabolism associated genes suggested the occurrence of metabolic reprogramming. We conclude that extracellular S100A4 stimulate the transition to the invasive phenotype in poorly-invasive melanoma cells, and that this transition is associated with metabolic reprogrammingve Total RNA was isolated from Melmet 1 and Melmet 5 cells stimulated with rS100A4 protein for 48hrs compared to non-stimulated cells.

2015-02-13 | E-GEOD-65897 | biostudies-arrayexpress

The effect on p53-induced gene transactivation by LIMA1 knockdown.

Project description:To explore the effect of LIMA1 on gene transactivation induced by p53, we evaluated the changes in gene expression by RNA-seq in LIMA1 knockdown or control A549 cells.

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S100A4+ Stromal Cells from Normal Lung vs. Metastatic Lung

Project description:Analysis of S100A4+ stromal cells at the gene expression level in physiological setting versus metastatic setting. Total RNA was isolated from FACS-sorted S100A4+ stromal cells from normal lung of S100A4-GFP transgenic mice compared to FACS-sorted S100A4+ stromal cells from metastatic lung of 4T1 tumor-bearing S100A4-GFP transgenic mice.

2011-08-29 | E-GEOD-31711 | biostudies-arrayexpress

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