Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ChIPseq to profile CDK9 occupancy in bone marrow-derived macrophages from C57BL/6 mice

ABSTRACT: ChIPseq to profile CDK9 occupancy in bone marrow-derived macrophages from C57BL/6 mice

PROVIDER: PRJNA504547 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8174614.fastq.gz	Fastqsanger.gz
	SRR8174615.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

ChIPseq to profile CDK9 and Hes1 occupancy in bone marrow-derived macrophages from C57BL/6 mice

Project description:We characterized the CDK9 and Hes1 occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs BMDMs were left untreated or stimulated with LPS for 1 hour. CDK9 or Hes1 ChIP was performed and the DNA products were subject to ChIPseq

2016-06-13 | E-GEOD-77334 | biostudies-arrayexpress

ChIPseq to profile CDK9 occupancy in bone marrow-derived macrophages from C57BL/6 mice

Project description:We characterized the CDK9 occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

2020-04-20 | GSE122300 | GEO

ChIPseq to profile CDK9 and Hes1 occupancy in bone marrow-derived macrophages from C57BL/6 mice

Project description:We characterized the CDK9 and Hes1 occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

2016-06-13 | GSE77334 | GEO

ChIPseq to profile NELFE occupancy in bone marrow-derived macrophages from C57BL/6 mice

Project description:ChIPseq to profile NELFE occupancy in bone marrow-derived macrophages from C57BL/6 mice

| PRJNA407767 | ENA

ChIPseq to profile NELFE occupancy in bone marrow-derived macrophages from C57BL/6 mice

Project description:We characterized the NELFE occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

2020-09-14 | GSE103950 | GEO

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism: Pol II occupancy profiling by ChIP-Seq in HeLa cell line in the presence or absence of CDK9 inhibition

Project description:CDK9 is the kinase subunit of P-TEFb that enables RNA polymerase (Pol) II to transit from promoter-proximal pausing to productive elongation. Although considerable interest exists in CDK9 as a therapeutic target, little progress has been made due to the lack of highly selective inhibitors. Here, we describe the development of i-CDK9 as such an inhibitor that potently suppresses CDK9 phosphorylation of substrates and causes genome-wide Pol II pausing. While most genes experience reduced expression, MYC and other primary response genes increase expression upon sustained i-CDK9 treatment. Essential for this increase, the bromodomain protein BRD4 captures P-TEFb from 7SK snRNP to deliver to target genes and also enhances CDK9’s activity and resistance to inhibition. Because the i-CDK9-induced MYC expression and binding to P-TEFb compensate for P-TEFb’s loss of activity, only the simultaneous inhibition of CDK9 and MYC can efficiently induce growth arrest and apoptosis of cancer cells, suggesting the potential of a combinatorial treatment strategy. ChIP-seq of Pol II in HeLa cells before or after i-CDk9 treatment

2015-06-17 | E-GEOD-60953 | biostudies-arrayexpress

ChIP-seq to profile Pol occupancy in bone marrow-derived macrophages from C57BL/6 mice

Project description:We characterized the PolII occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

2020-04-20 | GSE103795 | GEO

Genome-wide Analysis of Sp2 Occupancy and Expression Profiling Establish Sp2 as a Sequence-specific Transcription Factor Regulating Fundamental Cellular Processes - ChIPseq

Project description:Genome-wide Analysis of Sp2 Occupancy and Expression Profiling Establish Sp2 as a Sequence-specific Transcription Factor Regulating Fundamental Cellular Processes - ChIPseq

2012-05-24 | E-MTAB-994 | biostudies-arrayexpress

ChIP-seq to profile NELFE occupancy in bone marrow-derived macrophages from C57BL/6 mice II

Project description:We characterized the NELFE occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

2020-04-20 | GSE123557 | GEO

ChIP-seq to profile NELFE occupancy in bone marrow-derived macrophages from C57BL/6 mice II

Project description:ChIP-seq to profile NELFE occupancy in bone marrow-derived macrophages from C57BL/6 mice II

| PRJNA509216 | ENA