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Malignant transformation of normal mature mouse B cells into myeloma-like cells in vitro using defined genetic elements

ABSTRACT: Malignant transformation of normal mature mouse B cells into myeloma-like cells in vitro using defined genetic elements

PROVIDER: PRJNA506789 | ENA |

REPOSITORIES: ENA

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Malignant transformation of normal mature mouse B cells into myeloma-like cells in vitro using defined genetic elements

Project description:Expression of MYC+BMI1+BCLXL in normal mature mouse B cells results inmalignant transformation into lymphoma-like cells Expression of MYC+BMI1+BCLX+IRF4 in normal mature mouse B cells results in malignant transformation into myeloma-like cells

2019-05-08 | GSE122883 | GEO

Patterns of aberrant DNA methylation after toxicant-induced malignant transformation

Project description:This SuperSeries is composed of the following subset Series: GSE38926: Patterns of aberrant DNA methylation after toxicant-induced malignant transformation (MeDIP-chip dataset 1) GSE38928: Patterns of aberrant DNA methylation after toxicant-induced malignant transformation (MeDIP-chip dataset 2) GSE38929: Patterns of aberrant DNA methylation after toxicant-induced malignant transformation (miRNA dataset) Refer to individual Series

2012-06-25 | E-GEOD-38930 | biostudies-arrayexpress

Gene expression changes associated with malignant transformation of oral potentially malignant disorders

Project description:Gene expression changes associated with malignant transformation of oral potentially malignant disorders

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Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multi-step reactivation process

Project description:How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs rarely proliferate compared to their perinatal counterparts. Whether these relatively quiescent cells have the potential to transform is unknown, which is a critical question considering the late onset of human glioma. Additionally, the events taking place between initial mutation and a fully developed tumor mass (pre-malignant phase) are particularly poorly understood in glioma. Here we used a temporally controllable Cre transgene to delete p53 and NF1 specifically in adult OPCs, and demonstrated that these cells consistently give rise to malignant gliomas. To investigate the transforming process of quiescent adult OPCs, we then tracked these cells throughout the pre-malignant phase, which revealed a dynamic multi-step transformation, starting with rapid but transient hyper-proliferative reactivation, followed by a long period of dormancy, then final malignant transformation. Using pharmacological approaches, we discovered that mTOR signaling is critical for both the initial OPC reactivation step and late stage tumor cell proliferation, and thus might be a potential target for both glioma prevention and treatment. In summary, our results firmly establish the transforming potential of adult OPCs, and reveal an actionable multi-phasic reactivation process that turns slowly dividing OPCs into malignant gliomas.

2014-09-09 | GSE61282 | GEO

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multi-step reactivation process

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EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors

Project description:This SuperSeries is composed of the following subset Series: GSE32727: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human] GSE32904: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse] Refer to individual Series

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Gene expression analysis on arsenic-induced malignant transformation

Project description:Arsenic is environmental risk factor and has been linked to urothelial carcinoma incidence. Arsenic exposure-induced malignant transformed cells was established from normal urothelial cells by chronic arsenic exposure for 10 months. The purpose of the present study is to elucidate the relevant molecular alterationon on arsenic-induced malignant transformation.

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Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia

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2017-05-02 | PXD001963 | Pride

Gene expression changes associated with malignant transformation of oral potentially malignant disorders

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BTG1 mutation yields super-competitive B cells primed for malignant transformation

Project description:BTG1 mutation yields super-competitive B cells primed for malignant transformation

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