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A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (Nanostring III)

ABSTRACT: A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (Nanostring III)

PROVIDER: PRJNA506978 | ENA |

REPOSITORIES: ENA

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A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (Nanostring III)

Project description:Understanding the mechanisms that modulate T helper lymphocyte functions is crucial to decipher normal and pathogenic immune responses in humans. To identify molecular determinants influencing the pathogenicity of T cells, we separated ex vivo-isolated primary human memory T lymphocytes based on their ability to produce high levels of inflammatory cytokines. We found that the inflammatory, cytokine-producing phenotype of memory T lymphocytes was defined by a specific core gene signature and was mechanistically regulated by the constitutive activation of the NF-kB pathway and by the expression of the transcriptional repressor BHLHE40. BHLHE40 attenuated the expression of anti-inflammatory factors, including miR-146a, a negative regulator of NF-kB activation, and ZC3H12D, an RNase of the Regnase-1 family able to degrade inflammatory transcripts. Our data reveal a molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes, with the potential to contribute to disease.

2020-03-30 | GSE122945 | GEO

A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (Nanostring I)

Project description:A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (Nanostring I)

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