Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (ChIP-Seq)

ABSTRACT: A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (ChIP-Seq)

PROVIDER: PRJNA506984 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8244383.fastq.gz	Fastqsanger.gz
	SRR8244384.fastq.gz	Fastqsanger.gz
	SRR8244385.fastq.gz	Fastqsanger.gz
	SRR8244386.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

A molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes (Nanostring II)

Project description:Understanding the mechanisms that modulate T helper lymphocyte functions is crucial to decipher normal and pathogenic immune responses in humans. To identify molecular determinants influencing the pathogenicity of T cells, we separated ex vivo-isolated primary human memory T lymphocytes based on their ability to produce high levels of inflammatory cytokines. We found that the inflammatory, cytokine-producing phenotype of memory T lymphocytes was defined by a specific core gene signature and was mechanistically regulated by the constitutive activation of the NF-kB pathway and by the expression of the transcriptional repressor BHLHE40. BHLHE40 attenuated the expression of anti-inflammatory factors, including miR-146a, a negative regulator of NF-kB activation, and ZC3H12D, an RNase of the Regnase-1 family able to degrade inflammatory transcripts. Our data reveal a molecular network regulating the pro-inflammatory phenotype of human memory T lymphocytes, with the potential to contribute to disease.

2020-03-30 | GSE122943 | GEO