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Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula

ABSTRACT: Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula

PROVIDER: PRJNA507266 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8249180_1.fastq.gz	Fastqsanger.gz
	SRR8249180_2.fastq.gz	Fastqsanger.gz
	SRR8249190_1.fastq.gz	Fastqsanger.gz
	SRR8249190_2.fastq.gz	Fastqsanger.gz
	SRR8249181_1.fastq.gz	Fastqsanger.gz

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Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula

Project description:Genomic imprinting is an epigenetic mechanism by which genes are expressed in a parental-origin-dependent manner. We recently discovered that, like DNA methylation, oocyte-inherited H3K27me3 can also serve as an imprinting mark in mouse pre-implantation embryos. In this study, we found H3K27me3 is strongly biased toward the maternal allele with some associated with DNA methylation-independent paternally expressed genes (PEGs) in human morulae. The H3K27me3 domains largely overlap with DNA partially methylated domains (PMDs), and occupy developmental gene promoters. Thus, our study not only reveals the H3K27me3 landscape but also establishes a correlation between maternal-biased H3K27me3 and PEGs in human morulae.

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Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula.

Project description:Genomic imprinting is an epigenetic mechanism by which genes are expressed in a parental origin-dependent manner. We recently discovered that, like DNA methylation, oocyte-inherited H3K27me3 can also serve as an imprinting mark in mouse preimplantation embryos. In this study, we found H3K27me3 is strongly biased toward the maternal allele with some associated with DNA methylation-independent paternally expressed genes (PEGs) in human morulae. The H3K27me3 domains largely overlap with DNA partially methylated domains (PMDs) and occupy developmental gene promoters. Thus, our study not only reveals the H3K27me3 landscape but also establishes a correlation between maternal-biased H3K27me3 and PEGs in human morulae.

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