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Genome-wide H3K27me3 profile in in vitro produced bovine morula treated with MAT2A inhibitor

ABSTRACT: Genome-wide H3K27me3 profile in in vitro produced bovine morula treated with MAT2A inhibitor

PROVIDER: PRJNA814513 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18289163.fastq.gz	Fastqsanger.gz
	SRR18289164.fastq.gz	Fastqsanger.gz
	SRR18289165.fastq.gz	Fastqsanger.gz
	SRR18289166.fastq.gz	Fastqsanger.gz

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Genome-wide H3K27me3 profile in in vitro produced bovine morula treated with MAT2A inhibitor

Project description:We obtained genome-wide profiles of histone H3 lysine 27 trimethylation (H3K27me3) in bovine morula which had been in vitro treated with a methionine adenosyltransferase 2A (MAT2A) inhibitor from the 8-16 cell stage. Sequencing center: NODAI Genome Research Center, Tokyo University of Agriculture

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Transcriptomic profile in in vitro produced bovine morulae treated with MAT2A inhibitor

Project description:We obtained transcriptomic profiles in bovine morulae which had been in vitro treated with a methionine adenosyltransferase 2A (MAT2A) inhibitor from the 8-16 cell stage.

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Profile in in vitro produced bovine morulae treated with MAT2A inhibitor

Project description:Profile in in vitro produced bovine morulae treated with MAT2A inhibitor

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Transcriptomic profile in in vitro produced bovine morulae treated with MAT2A inhibitor

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Genome-wide H3K27me3 profile in in vitro produced bovine blastocysts

Project description:We aimed to obtain genome-wide profiles of histone H3 lysine 27 trimethylation (H3K27me3) in bovine blastocysts

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Genome-wide mapping of MAT2A-associsted regions in bovine blastocysts

Project description:Methionine adenosyltransferase (MAT), that catalyzes the synthesis of S-adenosylmethionine (SAM) from ATP and methionine, is involved in folate-mediated one-carbon metabolism (OCM) that is essential for preimplantation embryos in terms of both short-term periconceptional development and long-term phenotypic programming beyond the periconceptional period. SAM is the universal methyl donor for epigenetic methylation of DNA and histones. In the context of the long-term phenotypic programming by the modulation of OCM during periconceptional period, possible interactions between MAT2A and epigenetic status of specific genes during this period are of particular interest. MAT2A has been proposed to interact with many chromatin-related proteins and be recruited to their specific target genes to constitute gene-regulatory complexes. Thus, in the aim of addressing the possible interaction of MAT2A with specific genomic DNA regions in periconceptional period, we performed a ChIP-seq analysis using MAT2A antibody against bovine blastocysts.

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ChIP-seq profile in in vitro produced mouse morula stage embryos treated with siRNA targeting Pcgf5

Project description:We obtained H3K27me3 profiles in mouse morula stage embryos (72 h post-insemination (hpi)) which had been in vitro treated with siRNA targeting Pcgf5 from one-cell stage (3 hpi).

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MAT2A inhibitor in cancer cell lines

Project description:MAT2A inhibitor is dosed to MTAP null cell lines, samples are collected for transcriptome profiling

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KDM6A improves the efficiency of nuclear transfer reprogramming in bovine

Project description:As a histone hallmark for transcription repression, Histone H3 lysine 27 trimethylation (H3K27me3) plays important roles in mammalian embryo development and induced pluripotent stem cells (iPSCs) generation. However, the expression profile and roles of H3K27me3 in bovine somatic cell nuclear transfer (SCNT) reprogramming remain poorly understood. In this study, we find SCNT embryos exhibit global hypermethylation of H3K27me3 from two-cell to eight-cell stage and its removal by ectopically expressed H3K27me3 demethylase-KDM6A could greatly improves SCNT efficiency. To illuminate the mechanism of improving SCNT reprogramming efficiency of KDM6A overexpression, we performed RNA sequencing of transcripts in SCNT morula with or without KDM6A overexpression. RNA-seq reveal that KDM6A overexpression could enhance transcription of genes mainly involved cell adhesion and cellular metabolism process, as well as X-linked genes. We first provides the transcriptome data of bovine SCNT morula with or without KDM6A overexpression. Meanwhile, we compared the differences of transcriptome between SCNT eight-cell embryos and morula. Our study provide a more promising approach to improving the efficiency of SCNT reprogramming and contribute to understanding the mechanism of first cell fate determine during embryo development in bovine.

2019-01-31 | GSE114596 | GEO

High Glucose (HG) treated morula vs control glucose (CTL) treated morula

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