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Expression data from mouse cerebral cortex

ABSTRACT: Expression data from mouse cerebral cortex

PROVIDER: PRJNA508404 | ENA |

REPOSITORIES: ENA

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Expression data from mouse cerebral cortex

Project description:Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages Cerebral cortex from two mouse strains [C57BL/6J(B6) and C3H/J (C3H)] at post-natal day 1 (p1) and post-natal 11 weeks (11 wk) were harvested for microarray experiments

2013-10-21 | E-GEOD-46443 | biostudies-arrayexpress

Expression data from mouse cerebral cortex

2013-10-21 | GSE46443 | GEO

Metabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection

Project description:BACKGROUND: The protozoan parasite Toxoplasma gondii infects and alters the neurotransmission in cerebral cortex and other brain regions, leading to neurobehavioral and neuropathologic changes in humans and animals. However, the molecules that contribute to these changes remain largely unknown.METHODS: We have investigated the impact of T. gondii infection on the overall metabolism of mouse cerebral cortex. Mass-spectrometry-based metabolomics and multivariate statistical analysis were employed to discover metabolomic signatures that discriminate between cerebral cortex of T. gondii-infected and uninfected control mice.RESULTS: Our results identified 73, 67 and 276 differentially abundant metabolites, which were involved in 25, 37 and 64 pathways at 7, 14 and 21 days post-infection (dpi), respectively. Metabolites in the unsaturated fatty acid biosynthesis pathway were upregulated as the infection progressed, indicating that T. gondii induces the biosynthesis of unsaturated fatty acids to promote its own growth and survival. Some of the downregulated metabolites were related to pathways, such as steroid hormone biosynthesis and arachidonic acid metabolism. Nine metabolites were identified as T. gondii responsive metabolites, namely galactosylsphingosine, arachidonic acid, LysoSM(d18:1), L-palmitoylcarnitine, calcitetrol, 27-Deoxy-5b-cyprinol, L-homophenylalanine, oleic acid and ceramide (d18:1/16:0).CONCLUSIONS: Our data provide novel insight into the dysregulation of the metabolism of the mouse cerebral cortex during T. gondii infection and have important implications for studies of T. gondii pathogenesis.

2020-04-23 | MTBLS770 | MetaboLights

Expression data from mouse cerebral cortex

Project description:Cerebral cortex consists of many functional areas that are interconnected via direct axon projections from long association neurons. Long association neurons are located in layers 2/3, 5, and 6b. These neurons are intermingled with callosal neurons, which connect both cerebral hemisphere, in layers 2/3 and 5. To We used microarrays to compare gene expression profiles of long association neurons and callosal neurons in order to understand genetic programs that specifies these neuronal subtypes.

2019-06-17 | GSE123351 | GEO

Expression data of the Cerebral cortex in Tyr-Trp treated AD model mouse

Project description:Expression data of the Cerebral cortex in Tyr-Trp treated AD model mouse

| PRJNA610506 | ENA

Mouse cerebral cortex neurons proteomics response to West Nile Virus (WNV)

Project description:Proteomics data from mouse cerebral cortex neurons; Treated with wild-type and mutant WNV, and mockulum

2016-01-21 | MSV000079468 | MassIVE

Single-cell RNA-seq of mouse cerebral cortex

Project description:We have applied a recently developed, highly accurate and sensitive single-cell RNA-seq method (STRT/C1) to perform a molecular census of two regions of the mouse cerebral cortex: the somatosensory cortex and hippocampus CA1.

2015-02-20 | GSE60361 | GEO

Gene expression profilings of fetal human and mouse cerebral cortex exposed to alcohol

Project description:A dataset for coordinated transcriptome analysis of the effect of ethanol on human embryonic cerebral slices in vitro and on the mouse embryonic cerebral cortex in a in vivo model.

2010-08-13 | GSE23579 | GEO

WGBS from cerebral cortex (ENCSR277BIL)

Project description:Whole genome bisulfite-seq on 8 week adult mouse cerebral cortex For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-11-04 | GSE187299 | GEO

Expression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice

Project description:Expression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice

| PRJNA525078 | ENA