Project description:Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms brominated organic by-products and bromate. The carcinogenicity and chronic toxicity of potassium bromate (KBrO3) [CAS:7758-02-3;CHEBI:32030] was studied in male B6C3F1 mice and F344/N rats to confirm and extend the results of previous work. Mice were treated with 0, 0.08, 0.4, or 0.8 g/L KBrO3 in the drinking water for up to 100 wk, and rats were provided with 0, 0.02, 0.1, 0.2, or 0.4 g/L KBrO3. Animals were euthanatized, necropsied, and subjected to a complete macroscopic examination. Selected tissues and gross lesions were processed by routine methods for light microscopic examination. The present study showed that KBrO3 is carcinogenic in the rat kidney, thyroid, and mesothelium and is a renal carcinogen in the male mouse, KBrO3 was carcinogenic in rodents at water concentrations as low as 0.02 g/L (20 ppm; 1.5 mg/kg/day). These data can be used to estimate the human health risk that would be associated with changing from chlorination to ozonation for disinfection of drinking water.
2006-11-14 | E-TOXM-21 | biostudies-arrayexpress
Project description:Effect of disinfection method on biofilm bacterial community in domestic hot water system
| PRJNA624925 | ENA
Project description:Bacterial transcriptome after ultraviolet chlorine treatment
| PRJNA1061226 | ENA
Project description:Murine norovirus populations exposed to chlorine disinfection
| PRJNA939350 | ENA
Project description:Microbial community in RW chlorine dioxide disinfection
Project description:Minimal processing using chlorinated water washes is a common practice in the fresh produce industry to reduce the microbial load and bacterial pathogens attached on produce surfaces. To evaluate if E. coli O157:H7 strains with different phyllogenetic backgrounds are equally sensitive or display variable resistance to chlorine treatment, we studied the expression profile of Sakai and one 2006 spinach outbreak strain (TW 14359) in response to chlorine and hydrogen peroxide treatment.
Project description:Although drinking water disinfection has proved to be an effective strategy to eliminate most waterborne pathogens, bacterial pathogens can still show disinfection tolerance in drinking water distribution systems (DWDSs), posing a great threat to drinking water safety and human health. Despite stress signals such as starvation and low temperature were reported to increase disinfection tolerance of E. coli, it is unclear whether the stress-induced disinfection tolerance was conserved in different bacterial species.
Project description:Minimal processing using chlorinated water washes is a common practice in the fresh produce industry to reduce the microbial load and bacterial pathogens attached on produce surfaces. To evaluate if E. coli O157:H7 strains with different phyllogenetic backgrounds are equally sensitive or display variable resistance to chlorine treatment, we studied the expression profile of Sakai and one 2006 spinach outbreak strain (TW 14359) in response to chlorine and hydrogen peroxide treatment. Experiment Overall Design: 2 E. coli O157 strains are incubated with or without chlorine or H2O2 for 30 min for RNA extraction and hybridization on Affymetrix microarrays. We sought to compare the expression profile between the 2 strains with or without oxidative stress.
Project description:Interactive Impacts of water treatments on Microbial Communities in Water and Biofilms: Filtration, Chlorine and UV LED Disinfection
| PRJNA859934 | ENA
Project description:Disinfection effects of chlorine and hydrogen peroxide on airborne bacteria