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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers

ABSTRACT: Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers

PROVIDER: PRJNA509695 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8313200_1.fastq.gz	Fastqsanger.gz
	SRR8313200_2.fastq.gz	Fastqsanger.gz
	SRR8313210_1.fastq.gz	Fastqsanger.gz
	SRR8313210_2.fastq.gz	Fastqsanger.gz
	SRR8315000_1.fastq.gz	Fastqsanger.gz

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [ChIP-Seq]

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [ATAC-Seq]

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [HiC-seq]

Project description:Aposematic color pattern mimicry in Heliconius butterflies provides a well-known example of adaptation via selection on a few genes of large effect. To understand how selection at individual genes can drive the evolution of complex traits, we functionally characterized five novel enhancers of the color pattern gene, optix. In Heliconius erato we found that wing pattern enhancers are largely ancestral, pleiotropic, functionally interdependent, and introgressed between populations. Remarkably, many of these enhancers are also associated with regional pattern variation in the distantly related co-mimics Heliconius melpomene and Heliconius timareta. Our findings provide a case study of how parallel co-evolution of ancient, multifunctional regulatory elements can facilitate the rapid diversification of complex phenotypes, and provide a counterpoint to many widespread assumptions of cis-regulatory evolution.

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [ChIP-Seq]

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers

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2021-06-04 | GSE123704 | GEO

Parallel evolution of ancient, pleiotropic enhancers underlies butterfly wing pattern mimicry.

Project description:Color pattern mimicry in Heliconius butterflies is a classic case study of complex trait adaptation via selection on a few large effect genes. Association studies have linked color pattern variation to a handful of noncoding regions, yet the presumptive cis-regulatory elements (CREs) that control color patterning remain unknown. Here we combine chromatin assays, DNA sequence associations, and genome editing to functionally characterize 5 cis-regulatory elements of the color pattern gene optix We were surprised to find that the cis-regulatory architecture of optix is characterized by pleiotropy and regulatory fragility, where deletion of individual cis-regulatory elements has broad effects on both color pattern and wing vein development. Remarkably, we found orthologous cis-regulatory elements associate with wing pattern convergence of distantly related comimics, suggesting that parallel coevolution of ancestral elements facilitated pattern mimicry. Our results support a model of color pattern evolution in Heliconius where changes to ancient, multifunctional cis-regulatory elements underlie adaptive radiation.

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Contrasting roles of transcription factors spineless and EcR in the highly dynamic chromatin landscape of butterfly wing metamorphosis

Project description:Background: We studied the chromatin accessibility landscsape in wings during butterfly metamorphosis, and investigate which transcription factors might be driving changes in accessibility Methods: We sequencing the Junonia coenia genome, and we studied chromatin accessibility using ATAC seq in multiple stages of wing development in both forewings and hindwings. For sites showing a large change in accessibility, we investigate which motifs are enriched, and correlate this with changes in gene expression of associated transcription factors. We confirm promising candidates with ChIP-seq Results: We find a highly dynamic landscape, with multiple peaks showing a double increase in accessibility throughout development. We show that transcription factor spineless, but not ecdysone receptor, is highly predictive of opening sites Conclusions: This work provides a characterization of the chromatin dynamics of insect wing metamorphosis, identifies novel candidate chromatin remodeling factors in insects, and provides the first genome assembly of the model butterfly Junonia coenia, with gene and cis-regulatory element annotations

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