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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [HiC-seq]

ABSTRACT: Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [HiC-seq]

PROVIDER: PRJNA509699 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8315000_1.fastq.gz	Fastqsanger.gz
	SRR8315000_2.fastq.gz	Fastqsanger.gz
	SRR8315001_1.fastq.gz	Fastqsanger.gz
	SRR8315001_2.fastq.gz	Fastqsanger.gz
	SRR8315002_1.fastq.gz	Fastqsanger.gz

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [HiC-seq]

Project description:Aposematic color pattern mimicry in Heliconius butterflies provides a well-known example of adaptation via selection on a few genes of large effect. To understand how selection at individual genes can drive the evolution of complex traits, we functionally characterized five novel enhancers of the color pattern gene, optix. In Heliconius erato we found that wing pattern enhancers are largely ancestral, pleiotropic, functionally interdependent, and introgressed between populations. Remarkably, many of these enhancers are also associated with regional pattern variation in the distantly related co-mimics Heliconius melpomene and Heliconius timareta. Our findings provide a case study of how parallel co-evolution of ancient, multifunctional regulatory elements can facilitate the rapid diversification of complex phenotypes, and provide a counterpoint to many widespread assumptions of cis-regulatory evolution.

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers

Project description:Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [ChIP-Seq]

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [ATAC-Seq]

Project description:Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [ATAC-Seq]

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers [ChIP-Seq]

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Butterfly wing pattern mimicry radiated via parallel evolution of ancient, pleiotropic enhancers

Project description:This SuperSeries is composed of the SubSeries listed below.

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Parallel evolution of ancient, pleiotropic enhancers underlies butterfly wing pattern mimicry.

Project description:Color pattern mimicry in Heliconius butterflies is a classic case study of complex trait adaptation via selection on a few large effect genes. Association studies have linked color pattern variation to a handful of noncoding regions, yet the presumptive cis-regulatory elements (CREs) that control color patterning remain unknown. Here we combine chromatin assays, DNA sequence associations, and genome editing to functionally characterize 5 cis-regulatory elements of the color pattern gene optix We were surprised to find that the cis-regulatory architecture of optix is characterized by pleiotropy and regulatory fragility, where deletion of individual cis-regulatory elements has broad effects on both color pattern and wing vein development. Remarkably, we found orthologous cis-regulatory elements associate with wing pattern convergence of distantly related comimics, suggesting that parallel coevolution of ancestral elements facilitated pattern mimicry. Our results support a model of color pattern evolution in Heliconius where changes to ancient, multifunctional cis-regulatory elements underlie adaptive radiation.

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