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SRNA sequencing of HDL from human donors

ABSTRACT: sRNA sequencing of HDL from human donors

PROVIDER: PRJNA512494 | ENA |

REPOSITORIES: ENA

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sRNA sequencing of HDL from human donors

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Expression data from human coronary artery endothelial cells treated with HDL components

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Project description:The aim of this study was to identify HDL and apoE-regulated genes in human placental endothelial cells (HPEC), which are exposed to fetal HDL. HPECs extracted from 5 human placentas were cultivated and treated for 16 h with 15ug/ml fetal HDL, 15ug/ml reconstituted HDL (rHDL), or endothelial basal medium (EBM) as vehicle control. Gene expression analysis from these 3 conditions (5 biological replicates) using 15 Applied Biosystems Human Whole Genome Survey V2.0 Microarrays was perfomed and significantly differentially expressed genes between two different groups (HDL vs control or rHDL vs control) were identified.

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