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Balancing apelin and angiotensin-II signaling to reduce heart injury during weightlessness

ABSTRACT: Balancing apelin and angiotensin-II signaling to reduce heart injury during weightlessness

PROVIDER: PRJNA515729 | ENA |

REPOSITORIES: ENA

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Balancing apelin and angiotensin-II signaling to reduce heart injury during weightlessness

Project description:In order to further develop gene expression methods for simulated weightlessness, genome-wide microarray expression profiles were used as a discovery platform to identify genes differentially expressed in mice after simulated weightlessness. After 28 days of tail suspension simulated weightlessness in 10-week-old male C57BL/6 mice, 706 genes were identified to distinguish tail suspension from control samples.

2019-01-18 | GSE125274 | GEO

Impaired heart function in Apelin gene-deficient mice

Project description:The endogenous peptide Apelin is crucial for maintaining heart function in pressure overload and aging Keywords: knockout

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Transcription profiling of mouse heart samples from pressure overload and sham treated animals from wild type and Apelin knockouts reveals impaired heart function in Apelin

Project description:The endogenous peptide Apelin is crucial for maintaining heart function in pressure overload and aging Experiment Overall Design: Heart samples from Apelin knockout mice with pressure overload and sham control together with the wild-type mice with pressure overload and sham were compared

2008-06-15 | E-GEOD-7781 | biostudies-arrayexpress

Apelin absence in endothelial cells

Project description:First, transcriptome analysis of purified CD31+ endothelial cells (ECs) from VEGF-treated sprouting embryoid bodies showed angiogenesis as the top affected category when Apelin is not present. In addition, loss of Apelin resulted in the modulation of pathways in ECs related to vasculogenesis, cell adhesion and response to hypoxia. Ingenuity Pathway Analysis (IPA) further identified VEGFR pathway as the main upstream regulator affected in endothelial cells, closely followed by the TGFβ1 and TNF pathways, all reduced in the absence of Apelin. The most inhibited genes from the VEGFR pathway in the absence of Apelin are angiogenesis-related genes. Second, transcriptome analysis of CD31+/CD105+ ECs sorted from Apelin wild-type and Apln-depleted tumors found a significant decrease in processes associated with endothelial cell proliferation and angiogenesis in ECs sorted out of Apelin-depleted tumors using IPA. Further, IPA predicted a decrease in the adhesion of granulocytes and upstream regulator analysis showed that proteins of the TGF-superfamily, Inhibin-βA and TGF-β1, as well as C/EBP-alpha, β-Catenin, ErbB2 and EGFR are predicted to be inhibited upstream regulators in ECs isolated from Apelin-depleted tumors.

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Apelin/APJ targeted microRNAs in pulmonary artery endothelial cells

Project description:Evaluation of microRNAs that are downstream of apelin/APJ signaling in the pulmonary artery endothelial cells. Triplicates per group, subjected to: 1) control siRNA, 2) apelin siRNA, 3) APJ siRNA, 4) apelin + APJ siRNA

2012-12-04 | E-GEOD-42343 | biostudies-arrayexpress

Apelin promotes hematopoiesis from human embryonic stem cells

Project description:Analysis of genes enriched in MIXL1+ sorted cells during primitive streak induction identified Apelin receptor (APLNR), a highly conserved member of the G-protein coupled receptor family. Depending upon the growth factor conditions used for differentiation, APLNR+ cells identified both posterior mesodermal and anterior mesendodermal components of the primitive streak. APLNR+ cells isolated from mesodermal differentiated cultures were enriched in hematopoietic blast colony forming cells (Bl-CFCs) and the addition of Apelin peptide enhanced the frequency and growth of both hematopoietic colonies and hESC-derived endothelial cells. These studies identified APLNR as a marker of primitive streak-like cells differentiated from hESCs and defined a novel role for Apelin as a regulator of early human hematopoiesis.

2012-02-12 | E-MEXP-3380 | biostudies-arrayexpress

FoxO1 inhibition by apelin/APJ signaling in endothelial cells

Project description:Evaluation of gene transcripts that are downstream of apelin/APJ and FoxO1 signaling in HUVECs

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Apelin 13 breaks the immune cell route from lung to brain [scRNA-Seq]

Project description:To investigate the effect of Apelin 13 on lung in experimental autoimmune encephalomyelitis(EAE) at peak, we perform single cell RNA sequencing of the whole lung of Control, EAECont and EAE with Apelin 13 treatment(EAEA13)

2024-06-14 | GSE230550 | GEO

Apelin/APJ targeted microRNAs in pulmonary artery endothelial cells

Project description:Evaluation of microRNAs that are downstream of apelin/APJ signaling in the pulmonary artery endothelial cells.

2012-12-04 | GSE42343 | GEO

Apelin 13 breaks the immune cell route from lung to brain [RNA-Seq]

Project description:We treated HUVEC with Apelin 13 or siRNA of Aplnr to investigate the impact of Apelin 13 and APLNR knockdown. We then performed gene expression profiling analysis using data obtained from RNA-seq of 7 different conditions.

2024-06-14 | GSE230549 | GEO

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