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Small RNA sequencing reveals new mode of action and potential biomarkers for the mycotoxin Zearalenone

ABSTRACT: Small RNA sequencing reveals new mode of action and potential biomarkers for the mycotoxin Zearalenone

PROVIDER: PRJNA524102 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8618160.fastq.gz	Fastqsanger.gz
	SRR8618170.fastq.gz	Fastqsanger.gz
	SRR8618180.fastq.gz	Fastqsanger.gz
	SRR8618161.fastq.gz	Fastqsanger.gz
	SRR8618171.fastq.gz	Fastqsanger.gz

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Small RNA sequencing reveals new mode of action and potential biomarkers for the mycotoxin Zearalenone

Project description:Purpose: The mycotoxin zearalenone (ZEN) poses a risk to animal health because of its estrogenic effects. Diagnosis of ZEN-induced disorders in animal production remains challenging due to the lack of appropriate non-invasive biomarkers. Thus, we combined untargeted and targeted transcriptomics approaches to investigate the effects of ZEN on the microRNA expression in porcine uterus, jejunum and serum. Methods: twenty-four piglets received either uncontaminated feed (Control) or feed containing 0.17 mg/kg ZEN (ZEN low), 1.46 mg/kg ZEN (ZEN medium) and 4.58 mg/kg ZEN (ZEN high) for 28 days. microRNA from uterus and jejunum tissues were profiled by next-generation small RNA sequencing. Serum microRNA expression was analyzed by RT-qPCR analysis. Results: the microRNA expression in the jejunum remained unaffected, while significant changes in the uterine microRNA profile were observed. Importantly, 14 microRNAs were commonly and in a dose-dependent manner affected in both the ZEN medium and ZEN high group, including microRNAs from the miR-503 cluster. Although the effects in the serum were less pronounced, the receiver operating characteristic analysis revealed that several microRNA ratios were able to discriminate properly between non-exposed and ZEN-exposed pigs (e.g. ssc-miR-135a-5p/ssc-miR-432-5p, ssc-miR-542-3p/ssc-miR-493-3p). Conclusions: This work sheds some new light on the molecular mechanisms of ZEN, and fosters biomarker discovery.

2019-07-16 | GSE126989 | GEO

Expression profiling of the genes responding to zearalenone and its analogues using estrogen-responsive genes.

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Expression profiling of the genes responding to zearalenone and its analogues using estrogen-responsive genes.

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Project description:This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/The drug Praziquantel is the most commonly used drug for parasitic flatworms. It is currently being increasingly used in mass drug administration programmes, raising concerns over whether resistance will develop. Although widely used, its mode of action was until very recently uncertain. This study will investigate the praziquantel mode of action and resistance by sequencing the transcriptomes of Dugesia japonica and different stages and strains of S. mansoni.

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