CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA526716 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR8715430.fastq.gz | Fastqsanger.gz | |||
| SRR8715440.fastq.gz | Fastqsanger.gz | |||
| SRR8715431.fastq.gz | Fastqsanger.gz | |||
| SRR8715432.fastq.gz | Fastqsanger.gz | |||
| SRR8715433.fastq.gz | Fastqsanger.gz |
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Project description:This study examines the extent to which memory CD4+ T cells share immunosurveillance strategies with CD8+ resident memory T cells (TRM). After acute viral infection, memory CD4+ T cells predominantly used residence to survey nonlymphoid tissues, albeit not as stringently as observed for CD8+ T cells. In contrast, memory CD4+ T cells were more likely to be resident within lymphoid organs than CD8+ T cells. Migration properties of memory-phenotype CD4+ T cells in non-SPF parabionts were similar, generalizing these results to diverse infections and conditions. CD4+ and CD8+ TRM shared overlapping transcriptional signatures and location-specific features, such as granzyme B expression in the small intestine, revealing tissue-specific and migration property-specific, in addition to lineage-specific, differentiation programs. Functionally, mucosal CD4+ TRM reactivation locally triggered both chemokine expression and broad immune cell activation. Thus, residence provides a dominant mechanism for regionalizing CD4+ T cell immunity, and location enforces shared transcriptional, phenotypic, and functional properties with CD8+ T cells.
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