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LINC00266-1-encoded peptide regulates mRNA splicing

ABSTRACT: LINC00266-1-encoded peptide regulates mRNA splicing

PROVIDER: PRJNA527803 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8744430_1.fastq.gz	Fastqsanger.gz
	SRR8744430_2.fastq.gz	Fastqsanger.gz
	SRR8744431_1.fastq.gz	Fastqsanger.gz
	SRR8744431_2.fastq.gz	Fastqsanger.gz
	SRR8744432_1.fastq.gz	Fastqsanger.gz

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LINC00266-1-encoded peptide regulates mRNA splicing

Project description:The mRNA transcriptome profiling and splicing profiling mediated by LINC00266-1 and LINC00266-1-encoded peptide were investigated by RNA-seq.

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LOC90024-encoded small protein SRSP regulates mRNA splicing

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LOC90024-encoded small protein SRSP regulates mRNA splicing

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RRP1B is a Metastasis Modifier that Regulates the Transcriptome through mRNA Splicing

Project description:RRP1B is a Metastasis Modifier that Regulates the Transcriptome through mRNA Splicing To assess the role of RRP1B in alternative mRNA splicing, we knocked down the expression of Rrp1b in the highly metastatic mouse mammary tumor cell line Mvt-1 using shRNA. Two control and two knockdown stable cell lines were selected for RNA-sequencing.

2014-06-08 | E-GEOD-38669 | biostudies-arrayexpress

MOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis

Project description:Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA that yield bioactive peptides. Here we report the identification of a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open-reading-frame of the twelve S rRNA -c) that regulates insulin sensitivity and metabolic homeostasis. MOTS-c is detected in various tissues and in circulation in an age-dependent manner. Its primary target organ appears to be the skeletal muscle and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, causing a significant accumulation of AICAR levels concomitantly with AMPK activation. MOTS-c treatment in mice prevented age-dependent and high-fat diet-induced insulin resistance, as well as diet-induced obesity. These results suggest that mitochondria may be more actively engaged in regulating metabolic homeostasis than previously recognized, through the production of peptides encoded within its genome that act at the cellular and organismal level. Human embryonic kidney cells (HEK293 cell line) were cultured in 10-cm dishes in 7 mL of phenol-free DMEM supplemented with 10% FBS and incubated with water (controls) or the 16-amino-acid peptide mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c, 10 uM) for 4 or 72 hours prior to RNA extraction.

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RRP1B is a Metastasis Modifier that Regulates the Transcriptome through mRNA Splicing

Project description:RRP1B is a Metastasis Modifier that Regulates the Transcriptome through mRNA Splicing

2014-06-08 | GSE38669 | GEO

BCAS2 regulates oocyte meiosis by participating in alternative mRNA splicing

Project description:BCAS2 regulates oocyte meiosis by participating in alternative mRNA splicing

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MOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis

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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1

Project description:RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of gene expression. It is controlled by the spliceosome, a megadalton RNA-protein complex that assembles de novo on each pre-mRNA intron via an ordered assembly of intermediate complexes. Spliceosome activation is a major control step requiring dramatic protein and RNA rearrangements leading to a catalytically active complex. Splicing factor 3B subunit 1 (SF3B1) protein, a subunit of the U2 snRNP, is phosphorylated during spliceosome activation, but the responsible kinase has not been identified. Here we show that cyclin-dependent kinase 11 (CDK11) associates with SF3B1 and phosphorylates threonine residues at its N-terminus during spliceosome activation. The phosphorylation is important for association of SF3B1 with U5 and U6 snRNAs in spliceosome activated Bact complex and it can be blocked by OTS964, a potent and selective inhibitor of CDK11. CDK11 inhibition prevents spliceosomal transition from the precatalytic complex B to the activated complex Bact and leads to widespread intron retention and accumulation of non-functional spliceosomes on pre-mRNAs and chromatin. We characterize OTS964 as a quality chemical biology probe for CDK11 and demonstrate a central role of CDK11 in spliceosome assembly and splicing regulation.

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