Ontology highlight
ABSTRACT:
PROVIDER: PRJNA528554 | ENA |
REPOSITORIES: ENA
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Project description:Deep sequencing of mRNA from two macaques, crab-eating macaque and Indian rhesus macaque
2011-10-14 | GSE29629 | GEO
Project description:Deep sequencing of mRNA from two macaques, crab-eating macaque and Indian rhesus macaque Analysis of ploy(A)+ RNA of different specimens:brain,ileum,kidney,liver,testes and white adipose for crab-eating macaque while brain,heart,,kidney,liver,quadriceps and testes for Indian rhesus macaque
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Project description:Recent discoveries highlight the effectiveness of major histocompatibility complex (MHC)-E-restricted CD8+ T cell responses in controlling certain infections, particularly in a rhesus cytomegalovirus (RhCMV68-1)-vectored simian immunodeficiency virus (SIV) vaccine. In this context, these responses are preferentially elicited and are crucial for enabling vaccinated rhesus macaques to eradicate an SIV challenge. To harness human leukocyte antigen (HLA)-E-restricted CD8+ T cell responses for therapeutic purposes, it is essential to understand how these responses are primed, especially the mechanisms regulating MHC-E trafficking within endosomal pathways. Here, we identified a novel lysine/tryptophan-based motif in the HLA-E cytoplasmic tail that promotes rapid surface turnover via clathrin-mediated endocytosis. This motif, combined with strong binding peptides, also facilitates HLA-E recycling through a distinct valosin-containing protein-dependent pathway. Additionally, we show that this motif and its associated endosomal transport mechanisms are conserved in rhesus macaques and Mauritian-origin cynomolgus macaques. These findings advance our understanding of how MHC-E regulates immune functions through unconventional transport processes and offer insights for stimulating HLA-E-restricted CD8+ T cell responses in immunotherapy development.
2025-11-10 | PXD060886 | Pride
Project description:A single AAV vector dose delivering broadly neutralizing antibody 3BNC117 at birth provided over 3 years of protection against HIV-like infection in infant rhesus macaques. Neonatal administration was most effective due to immune tolerance, which reduced anti-drug antibodies and enabled sustained bNAb expression. This approach offers a promising one-time gene therapy strategy to prevent perinatal and adolescent HIV-1 infections. A total of 65 rhesus macaques (Macaca mulatta) of Indian origin were utilized in this study
2025-09-30 | GSE301418 | GEO
Project description:In this study three Indian rhesus macaques were infected with Simian Immunodeficiency Virus (SIVmac251). This generates a chronic infection mirroring AIDS in the animals. Prior to infection (day 0) and at two different time-points post-infection (day 21 and day 90), intestinal resection biopsies were performed. The intestinal tissue was then separated into different sub-sections including lamina-propria lymphocytes (LPL), intra-epithelial lymphocytes (IEL), stroma or matrix and epithelium. In this study we report the genome-wide transcriptional response at the two different time-points, specific to LPL, relative to pre-infection samples. For this purpose we have used the Affymetrix Rhesus Macaque GeneChip. 3 Rhesus Macaques prior to infection and 21 and 90 days of infection
2011-12-10 | E-GEOD-34300 | biostudies-arrayexpress
Project description:Sixteen individual rhesus macaque genomes were compared to a reference macaque genome (R354) on custom-designed sure-print 1M oligonucleotide microarray Agilent (Agilent Technologies) aCGH slide per manufacturer’s recommendations. a custom designed Agilent array-based comparative genomic hybridization (aCGH) platform, which comprises 950,843 unique 60-mer oligonucleotide probes specific to the rhesus macaque reference genome (rheMac2), to compare the genomic DNAs of 17 unrelated rhesus macaques of Indian origin to the genome of an unrelated sample from the same species.
2011-05-11 | E-GEOD-19881 | biostudies-arrayexpress
Project description:This SuperSeries is composed of the following subset Series: GSE33090: Dramatic effects of social behavior on gene regulation in rhesus macaques [Individual_expression] GSE34127: Dramatic effects of social behavior on gene regulation in rhesus macaques [Cell type_expression] GSE34128: Dramatic effects of social behavior on gene regulation in rhesus macaques [Bisulfite_seq] Refer to individual Series
2012-02-01 | E-GEOD-34129 | biostudies-arrayexpress