Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identify RNAs That are Bound by LARP7

ABSTRACT: Identify RNAs That are Bound by LARP7

PROVIDER: PRJNA528982 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8784402_1.fastq.gz	Fastqsanger.gz
	SRR8784402_2.fastq.gz	Fastqsanger.gz
	SRR8784403_1.fastq.gz	Fastqsanger.gz
	SRR8784403_2.fastq.gz	Fastqsanger.gz
	SRR8784404_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Identify RNAs That are Bound by LARP7

Project description:Anti-LARP7 RNA immunoprecipitation (RIP) coupled with RNA-seq assays showed significant enrichment of U6 snRNA, but not other 4 spliceosomal snRNAs, in LARP7 complexes in adult mouse testis.

2019-11-07 | GSE128831 | GEO

Identification of small RNAs interacting with LARP7

Project description:The La-related protein LARP7 has been mainly described as a component of the 7SK small nuclear ribonucleoprotein (snRNP) complex, which negatively regulates RNA polymerase II by sequestering the positive transcription elongation factor b (P-TEFb). In our studies, we discovered a novel, 7SK snRNP-independent function of LARP7. We show that LARP7 interacts with the U6 spliceosomal RNA as well as with the small nucleolar RNAs (snoRNAs) directing the 2'-O-methylations of U6. Importantly, in the absence of LARP7, significantly less 2'-O-methylations are deposited on U6 affecting splicing fidelity. Mutations in the LARP7 gene have been associated with the Alazami syndrome, a form of primordial dwarfism characterized by intellectual disability. We describe a novel loss-of-function mutation of LARP7 occurring in Alazami patients and detect reduced 2'-O-methylations of U6 in patient-derived samples. Thus, aberrant posttranscriptional RNA modifications of the spliceosomal U6 snRNA may contribute to the development of this severe disease.

2020-02-03 | GSE126592 | GEO

Identification of small RNAs interacting with LARP7

Project description:Identification of small RNAs interacting with LARP7

| PRJNA522462 | ENA

Identification of small RNAs interacting with FLAG/HA(FH)-tagged LARP7

2020-02-03 | GSE126591 | GEO

Identifying Zmat3-bound RNAs

Project description:Identifying Zmat3-bound RNAs

| PRJNA607540 | ENA

Identifying Zmat3-bound RNAs

Project description:The goal of the study was to identify RNAs bound by Zmat3 using eCLIP.

2020-11-06 | GSE145555 | GEO