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RNA sequencing of human macrophages treated with iron chelator deferiprone (DEF), with and without lipopolysaccharide (LPS)

ABSTRACT: RNA sequencing of human macrophages treated with iron chelator deferiprone (DEF), with and without lipopolysaccharide (LPS)

PROVIDER: PRJNA529210 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8787290_1.fastq.gz	Fastqsanger.gz
	SRR8787290_2.fastq.gz	Fastqsanger.gz
	SRR8787291_1.fastq.gz	Fastqsanger.gz
	SRR8787291_2.fastq.gz	Fastqsanger.gz
	SRR8787292_1.fastq.gz	Fastqsanger.gz

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RNA sequencing of human macrophages treated with iron chelator deferiprone (DEF), with and without lipopolysaccharide (LPS)

Project description:In order to identify transcript changes in response to DEF , we used human macrophages with or without DEF treatment. In order to study the effect of iron chelation on LPS-polarized macrophage transcriptome, we exposed DEF-treated or control macrophages to short time exposure to LPS. We then performed whole-genome transcriptome sequencing by RNA-sequencing (RNA-seq).

2019-07-09 | GSE128885 | GEO

Treatment of a human lymphoblastoid cell line with the iron chelator deferoxamine

Project description:We treated lymphoblast cells with the iron chelator deferoxamine (DFO) for 60 hours to determine if iron chelation would affect the levels of intron lariats.

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CITE-seq of LSK cells from aged mice after long-term iron chelator regimen

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Transcription profiling of human HeLa cells grown to subconfluent density and CaCo-2 cells grown to high density treated with an iron source (hemin) or an iron chelator (desferal)

Project description:HeLa cells grown to subconfluent density and CaCo-2 cells grown to high density were either treated with an iron source (hemin) or an iron chelator (desferal). Cells were harvested and RNA was prepared by RNA-Clean (Hybaid-AGS) and the RNA was subjected to a subsequent clean up using the RNeasy (Qiagen) clean up procedure.

2006-04-05 | E-MANP-1 | biostudies-arrayexpress

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Transcriptomics analysis of iron chelator deferoxamine treated human tumor colonoids.

Project description:Transcriptomics analysis of iron chelator deferoxamine treated human tumor colonoids.

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RNA-seq of Highly Metastatic and Lowly Metastatic 4T1 Single Clones Treated with Iron Chelator Deferasirox (DFX)

Project description:Using bulk RNA-seq, the transcriptional profile of two cell lines with high or low metastatic properties derived from single clones of the murine 4T1 cell line treated or untreated with iron chelator DFX was analyzed in order to determine the mechanism underlying the inhibition preference of DFX for highly metastatic 4T1 cells.

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RNA-seq analysis to examine the effect of the iron chelator deferoxamine on gene expression profile in 3T3-L1 pre-adipocyte cells

Project description:Adipocyte differentiation has been shown to require iron, but the underlying mechanism remains elusive. Ferrous iron ion is known to function as a co-factor for alpha-ketoglutarate-dependent dioxygenases, including demethylases for histones, DNA, and RNA. Previously we reported several alpha-ketoglutarate-dependent histone demethylases as critical epigenetic regulators during adipogenesis. These lines of evidence led us to hypothesize that iron orchestrates epigenetic/epitranscriptional regulations during adipogenesis by controlling demethylation activities. In this study, we conducted genome-wide analysis on methylation landscapes of histones, DNA, and RNA in differentiation of 3T3-L1 pre-adipocytes. Using the iron chelator deferoxamine, we demonstrate here how dynamically methylation levels of histones, DNA, and RNA are regulated by iron during adipogenesis.

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