Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

ABSTRACT: Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

PROVIDER: PRJNA529677 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8799880.fastq.gz	Fastqsanger.gz
	SRR8799873.fastq.gz	Fastqsanger.gz
	SRR8799874.fastq.gz	Fastqsanger.gz
	SRR8799875.fastq.gz	Fastqsanger.gz
	SRR8799876.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

Project description:Respiratory failure is a life-threatening problem for pre-term and term infants, yet many causes remain unknown. Here, we present evidence that whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (Wfdc2), a protease inhibitor previously unrecognized in respiratory disease, may be a causal factor in infant respiratory failure. Wfdc2 transcripts are detected in the embryonic lung and analysis of a Wfdc2-GFP knock-in mouse line shows that both basal and club cells, and type II alveolar epithelial cells (AECIIs), express Wfdc2 neonatally. Wfdc2-null-mutant mice display progressive atelectasis after birth with a lethal phenotype. Mutant lungs have multiple defects, including impaired cilia and the absence of mature club cells from the tracheobronchial airways, and malformed lamellar bodies in AECIIs. RNA sequencing shows significant activation of a pro-inflammatory pathway, but with low-quantity infiltration of mononuclear cells in the lung. These data demonstrate that Wfdc2 function is vitally important for lung aeration at birth and that gene deficiency likely causes failure of the lung mucosal barrier.

2019-10-23 | GSE129006 | GEO

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice.

Project description:Respiratory failure is a life-threatening problem for pre-term and term infants, yet many causes remain unknown. Here, we present evidence that whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (Wfdc2), a protease inhibitor previously unrecognized in respiratory disease, may be a causal factor in infant respiratory failure. Wfdc2 transcripts are detected in the embryonic lung and analysis of a Wfdc2-GFP knock-in mouse line shows that both basal and club cells, and type II alveolar epithelial cells (AECIIs), express Wfdc2 neonatally. Wfdc2-null-mutant mice display progressive atelectasis after birth with a lethal phenotype. Mutant lungs have multiple defects, including impaired cilia and the absence of mature club cells from the tracheo-bronchial airways, and malformed lamellar bodies in AECIIs. RNA sequencing shows significant activation of a pro-inflammatory pathway, but with low-quantity infiltration of mononuclear cells in the lung. These data demonstrate that Wfdc2 function is vitally important for lung aeration at birth and that gene deficiency likely causes failure of the lung mucosal barrier.

| S-EPMC6899016 | biostudies-literature

Cheese whey

Project description:Cheese whey Metagenome (DC4)

| PRJNA497528 | ENA

Cheese whey

Project description:Cheese whey Metagenome (DC1)

| PRJNA529354 | ENA

Cheese whey

Project description:Cheese whey Metagenome (DC2)

| PRJNA497526 | ENA

Cheese whey (DC3)

Project description:Cheese whey Metagenome (DC3)

| PRJNA529357 | ENA

Postprandial effects of protein from salmon by-products and whey on gene expression in liver cells.

Project description:Exploring the metabolic effects of fish protein is important, as by-products from fish contain large amounts of proteins that could be used for human consumption. The aim of this study was to investigate the postprandial effects of intake of protein from salmon by-products, compared to whey. As part of this effort, the effects on gene expression in liver cells were studied in vitro. This was done by incubating HepG2 cells with human serum taken before (fasting) or 30 and 60 min after intake of salmon protein or whey and comparing that with HepG2 cells incubated in serum-free medium. Transcriptomic profiling of the cells was done with RNA sequencing.

2022-04-12 | GSE178584 | GEO

Protease Treatment

Project description:Determine if transcripts are released by protease treatment Keywords: Comparison of protease treatments

2005-12-01 | GSE3686 | GEO

Randomized trial of whey protein to prevent colorectal neoplasia

Project description:Interventions: Whey protein Placebo Primary outcome(s): After taking whey protein for 1 year, the prevention of colorectal neoplasia will be examined with colonoscopy. Study Design: Parallel Randomized

| 2647867 | ecrin-mdr-crc

Soybean whey wastewater bacteria

Project description:Soybean whey wastewater bacteria Raw sequence reads

| PRJNA1012818 | ENA