Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional profiling of endothelial cells lacking Flvcr2

ABSTRACT: Transcriptional profiling of endothelial cells lacking Flvcr2

PROVIDER: PRJNA532928 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8903060.fastq.gz	Fastqsanger.gz
	SRR8903061.fastq.gz	Fastqsanger.gz
	SRR8903062.fastq.gz	Fastqsanger.gz
	SRR8903063.fastq.gz	Fastqsanger.gz
	SRR8903064.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Transcriptional profiling of endothelial cells lacking Tgfbr2

Project description:Transcriptional profiling of endothelial cells lacking Tgfbr2

| PRJNA610654 | ENA

Transcriptional profiling of endothelial cells lacking Tgfbr2

Project description:Tgfbr2 controls signal transduction after binding activated Tgfb1. Inactivation of this receptor in endothelium results in vascular dysplasia and severe hemorrhage. Here, we define the transcriptional profile of endothelial cells lacking Tgfbr2.

2020-05-06 | GSE146487 | GEO

Transcriptional profiling of embryos lacking Flvcr1

Project description:Transcriptional profiling of embryos lacking Flvcr1

| PRJNA913440 | ENA

Transcriptional profiling of endothelial cells lacking Flvcr2

Project description:Flvcr2 is a putative heme transporter expressed in endothelial cells of the brain. Mutations in this gene in humans is the cause of Fowler syndrome, in which newborns show malformed brain blood vessels. We generated a mouse model of this disease by knocking out the mouse ortholog of the gene (Flvcr2). These mouse mutants recapitulate the human phenotype. To understand the molecular changes associated with Flvcr2 deletion, we defined the transcriptional profile of heterozygous and mutant endothelial cells. We observed changes in gene expression consistent with altered angiogenesis and metabolic pathways necessary for endothelium homeostasis.

2020-05-06 | GSE129838 | GEO

Transcriptional profiling of melanoma-associated lymphatic endothelial cells (LECs)

Project description:Transcriptional profiling of melanoma-associated lymphatic endothelial cells (LECs)

| PRJNA839387 | ENA

Transcriptional profiling of conditional knockout mice lacking Izumo1r in FoxP3+ Tregulatory cells

Project description:Transcriptional profiling of conditional knockout mice lacking Izumo1r in FoxP3+ Tregulatory cells

| PRJNA796609 | ENA

Identification of transcriptional drifts in endothelial cells associated with environmental changes

Project description:Environmental cues, such as shear stress and heterotypic cell interactions play a critical role in endothelial cell function, yet their unique contributions to the endothelial cell transcriptome remain unclear. Using cell preparations from human umbilical cords (ex vivo), we performed individual sample analysis to assess transcriptional drifts associated with environmental changes but independent of sex or background. Global gene expression profiling by RNA-seq, ATACseq, and MS/MS directed proteomics distinguished freshly isolated endothelial cells from genetically matched culture (in vitro) samples. Over 43% of the transcriptome was significantly changed by the in vitro environment. Amongst several signatures, we observed that TGF-beta and BMP target genes were reduced. In contrast, cytoskeleton-based processes and proliferation-related genes were increased. Subjecting cultured cells to long-term shear stress significantly rescued the expression of approximately 17% of genes including targets of BMP and Notch signaling known to be sensitive to flow. In contrast, co-culture of endothelial cells with smooth muscle cells normalized networks related to cell growth and differentiation, clathrin-vesicle related genes, and recovered targets downstream TGF-beta, recovering approximately 9% of the original in vivo signature. Our findings highlight specific genes, pathways and functional features of endothelial cells that require contextual information and exposure to physical forces. This transcriptional modulation is important to consider in all paradigms that are focused on understanding the ability of endothelial cells to maintain homeostasis and respond to disease processes.

2023-07-20 | PXD020958 | Pride

Transcriptional profiling of MST1 or FOXO1 depleted human umbilical vein endothelial cells

Project description:Transcriptional profiling of MST1 or FOXO1 depleted human umbilical vein endothelial cells

| PRJNA476865 | ENA

Expression profiling of human aortic endothelial cells vs human dermal endothelial cells

Project description:Expression profiling of human aortic endothelial cells vs human dermal endothelial cells

| PRJNA833298 | ENA

SUMOylation fine tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis

Project description:Reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine tuning the transcriptional activity of HEY1. Specifically, S UMOylation facilitates the formation of the HEY1 transcriptional complex and enhances its DNA binding capability in endothelial cells.

2023-08-18 | PXD044611 |

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data