Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts [BiSulfite-seq]

ABSTRACT: Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts [BiSulfite-seq]

PROVIDER: PRJNA533081 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8907830.fastq.gz	Fastqsanger.gz
	SRR8907840.fastq.gz	Fastqsanger.gz
	SRR8907831.fastq.gz	Fastqsanger.gz
	SRR8907841.fastq.gz	Fastqsanger.gz
	SRR8907832.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts

Project description:Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts

| PRJNA533079 | ENA

Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts [BiSulfite-seq]

Project description:Antenatal hypoxia has critial impacts on fetal heart development. The molecular mechanism of the antenaltal hypoxia effect on the heart development is still unknown. We performed DNA methylome and transcriptome analyses of antenatal hypoxia induced rat fetal and adult offspring hearts to understand the hypoxia-mediated epigenomic programming in the heart development. Heart tissue from fetal (E21) and adult rat (5 months old) were collected. mRNA and genomic DNA methylation profiles of the heart tissue were generated by RNAseq and reduced representation bisulfite seuqencing (RRBS) techniques. We found 323 and 112 differential expressed genes between control and hypoxia groups in the fetal and adult hearts, respectively. Meanwhile, 2828 and 2193 differential methylated regions were identified in the fetal and adult hearts. Furthermore, opposite gobal DNA methylation pattern changes in transcription start site regions (TSS ± 1kb) were observed between fetal and adult hearts. Combining transcriptome, data indicates a significant difference in the responding genes and pathways between fetal and adult hearts in responding to the antenatal hypoxia. Our study provides an initial framework and new insights into fetal hypoxia-mediated epigenetic programming of pro-inflammatory phenotype in the heart development, linking antenatal stress, and developmental programming of heart vulnerability to disease later in life.

2019-04-25 | GSE129874 | GEO

Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts [RNA-seq]

Project description:Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts [RNA-seq]

| PRJNA533075 | ENA

Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts [RNA-seq]

2019-04-25 | GSE129848 | GEO

Prenatal hypoxia exposure induced methylomic and transcriptomic alterations in rat hearts

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-04-25 | GSE129876 | GEO

Transcriptomic and methylomic analyses of liver tissue in nonalcoholic steatohepatitis [Bisulfite-Seq]

Project description:Transcriptomic and methylomic analyses of liver tissue in nonalcoholic steatohepatitis [Bisulfite-Seq]

| PRJNA977888 | ENA

BDE-47 CpG Methylomic Alterations in Human Embryonic Stem Cell-derived Neural Precursor Cells

Project description:Methylomic characterization of BDE-47 exposures in human neural precursor cells

2019-05-01 | GSE125465 | GEO

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.

Project description:Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describe a systematic study of schizophrenia-associated methylomic variation in the adult brain and its relationship to changes in DNA methylation across human fetal brain development. Results: We profile methylomic variation in matched prefrontal cortex and cerebellum brain tissue from schizophrenia patients and controls, identifying disease-associated differential DNA methylation at multiple loci, particularly in the prefrontal cortex, and confirming these differences in an independent set of adult brain samples. Our data reveal discrete modules of co-methylated loci associated with schizophrenia that are enriched for genes involved in neurodevelopmental processes and include loci implicated by genetic studies of the disorder. Methylomic data from human fetal cortex samples, spanning 23 to 184 days post-conception, indicates that disease-associated differentially methylated positions are significantly enriched for loci at which DNA methylation is dynamically altered during human fetal brain development. Conclusions: Our data support the hypothesis that schizophrenia has an important early neurodevelopmental component, and suggest that epigenetic mechanisms may mediate these effects. 33 post-mortem brain (prefrontal cortex) samples (18 schizophrenia cases and 15 controls) were obtained from Douglas Bell-Canada Brain Bank (DBCBB), Montreal, Canada. Bisulfite converted DNA from these samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip v1.0.

2014-09-13 | E-GEOD-61380 | biostudies-arrayexpress

Profiling Methylomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders

Project description:Analysis of methylomic alternations related with alcohol use disorders (AUD). The hypothesis is that chronic alcohol consumption might alter genome-wide DNA methylation patterns. The results suggest that differential DNA methylation might be invovled in neuradaptations to alcohol. Genomic DNA was extraced from postmortem prefrontal cortex tissues of 23 AUD cases and 23 matched controls. Both AUD cases and matched controls are assessed with DSM-IV

2013-11-06 | E-GEOD-49393 | biostudies-arrayexpress

Profiling Methylomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders

2013-11-06 | GSE49393 | GEO