Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

ABSTRACT: Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

PROVIDER: PRJNA541240 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9016990_1.fastq.gz	Fastqsanger.gz
	SRR9016990_2.fastq.gz	Fastqsanger.gz
	SRR9017000_1.fastq.gz	Fastqsanger.gz
	SRR9017000_2.fastq.gz	Fastqsanger.gz
	SRR9017010_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 74

Similar Datasets

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

Project description:Endothelial ERK1/2 pathway plays a crucial role in maintenance of endothelial homeostasis. Its suppression results in activation of TGFΒ signaling, leading to hypertension, renal failure, fibrosis and sudden death, findings similar to those observed in patients treated with anti-VEGF agents.

2019-05-07 | GSE130737 | GEO

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium.

Project description:To define the role of ERK1/2 signaling in the quiescent endothelium, we induced endothelial Erk2 knockout in adult Erk1-/- mice. This resulted in a rapid onset of hypertension, a decrease in eNOS expression, and an increase in endothelin-1 plasma levels, with all mice dying within 5 wk. Immunostaining and endothelial fate mapping showed a robust increase in TGFβ signaling leading to widespread endothelial-to-mesenchymal transition (EndMT). Fibrosis affecting the cardiac conduction system was responsible for the universal lethality in these mice. Other findings included renal endotheliosis, loss of fenestrated endothelia in endocrine organs, and hemorrhages. An ensemble computational intelligence strategy, comprising deep learning and probabilistic programing of RNA-seq data, causally linked the loss of ERK1/2 in HUVECs in vitro to activation of TGFβ signaling, EndMT, suppression of eNOS, and induction of endothelin-1 expression. All in silico predictions were verified in vitro and in vivo. In summary, these data establish the key role played by ERK1/2 signaling in the maintenance of vascular normalcy.

| S-EPMC6683988 | biostudies-literature

Autophagy maintains intestinal stem cell integrity

Project description:Autophagy maintains intestinal stem cell integrity

| PRJNA564106 | ENA

Mitochondrial respiration is necessary to combat oxidative stress in quiescent cells

Project description:Mitochondrial oxidative phosphorylation (OXPHOS) makes ATP and supports biosynthesis during proliferation, but its role in non-proliferating cells, beyond ATP production, is less understood. Here we show that OXPHOS protects quiescent (but not proliferating) cells from oxidative stress. Using in vivo models of OXPHOS deficiency (whole body and endothelium-specific) we show that OXPHOS mediated resistance to ROS (i) maintains selectivity of ROS-based anticancer therapy by protecting normal tissues during treatment, and in quiescent endothelium (ii) ameliorates systemic LPS-induced inflammation and (iii) attenuates symptoms of the inflammatory bowel disease. ROS-resistance provided by OXPHOS is independent of its role in biosynthesis or NADH recycling. Instead, in quiescent cells OXPHOS constitutively generates low levels of endogenous ROS that support basal autophagic flux and protect from exogenous ROS challenge. Hence, during evolution cells acquired mitochondria to profit from oxidative metabolism, but also built in an OXPHOS-dependent mechanism to guard against the resulting oxidative stress.

2022-10-13 | PXD021376 | Pride

Hormone-responsive Bmpr1a maintains myoepithelial integrity during pregnancy

Project description:Hormone-responsive Bmpr1a maintains myoepithelial integrity during pregnancy

| PRJNA691166 | ENA

Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis

Project description:Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis

| PRJNA338316 | ENA

BRCA1 maintains telomere integrity through suppression of TERRA RNA and TERRA R-loop-induced DNA damage

Project description:Data in support of Vohhodina et al. "BRCA1 maintains telomere integrity through suppression of TERRA RNA and TERRA R-loop-induced DNA damage"

2021-04-21 | MSV000087276 | MassIVE

DNA methylation maintains integrity of higher order genome architecture

Project description:DNA methylation maintains integrity of higher order genome architecture

| PRJNA663616 | ENA

Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport

Project description:Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport

| PRJNA1040298 | ENA

SRSF2 transcriptional function maintains genome integrity during cell division

Project description:SRSF2 transcriptional function maintains genome integrity during cell division

| PRJNA914312 | ENA