Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The role of CIC in brain development and neuronal differentiation (RNA-Seq)

ABSTRACT: The role of CIC in brain development and neuronal differentiation (RNA-Seq)

PROVIDER: PRJNA543148 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9066670.fastq.gz	Fastqsanger.gz
	SRR9066671.fastq.gz	Fastqsanger.gz
	SRR9066668.fastq.gz	Fastqsanger.gz
	SRR9066669.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

The role of CIC in brain development and neuronal differentiation

Project description:The role of CIC in brain development and neuronal differentiation

| PRJNA543146 | ENA

The role of CIC in brain development and neuronal differentiation (ChIP-Seq)

Project description:The role of CIC in brain development and neuronal differentiation (ChIP-Seq)

| PRJNA543150 | ENA

The role of CIC in brain development and neuronal differentiation (ChIP-Seq)

Project description:ChIP-seq analysis of CIC and H3K27Ac in the developing mouse brain

2020-04-15 | GSE131301 | GEO

The role of CIC in brain development and neuronal differentiation (RNA-Seq)

Project description:RNA_seq analysis for Nes Cre;CIC+/+ vs.Nes Cre;CICflox/flox mouse brain

2020-04-15 | GSE131299 | GEO

The role of CIC in brain development and neuronal differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-04-15 | GSE131302 | GEO

Multi-omic analyses reveal interaction networks linking CIC to cell cycle regulation

Project description:CIC encodes a transcriptional repressor inactivated by loss-of-function mutations in several cancer types, indicating that it may function as a tumor suppressor. Recent data indicate that CIC may regulate cell cycle genes in humans; however, a thorough investigation of this proposed role has not yet been reported. Here, we used single-cell RNA sequencing technology to provide evidence that inactivation of CIC in human cell lines resulted in transcriptional dysregulation of genes involved in cell cycle control. We also mapped CIC’s protein-protein and genetic interaction networks, identifying interactions between CIC and members of the Switch/Sucrose Non-Fermenting (SWI/SNF) complex, as well as novel candidate interactions between CIC and cell cycle regulators. We further showed that CIC loss was associated with an increased frequency of mitotic defects in human cell lines and a mouse model. Overall, our study positions CIC as a cell cycle regulator and indicates that CIC loss can lead to mitotic errors, consistent with CIC’s emerging role as a tumor suppressor of relevance in several cancer contexts.

2023-06-30 | PXD030942 | Pride

Emergence of neuronal diversity during vertebrate brain development

Project description:Emergence of neuronal diversity during vertebrate brain development

| PRJNA664124 | ENA

BRG1 role in neuronal activity

Project description:BRG1 role in neuronal activity

| PRJNA730575 | ENA

CIC is a critical regulator of neuronal differentiation.

Project description:Capicua (CIC), a member of the high mobility group-box (HMG-box) superfamily of transcriptional repressors, is frequently mutated in human oligodendrogliomas. However, its functions in brain development and tumorigenesis remain poorly understood. Here, we report that brain-specific deletion of Cic compromises developmental transition of neuroblasts to immature neurons in mouse hippocampus and compromises normal neuronal differentiation. Combined gene expression and ChIP-seq analyses identified VGF as an important CIC-repressed transcriptional surrogate involved in neuronal lineage regulation. Aberrant VGF expression promotes neural progenitor cell proliferation by suppressing their differentiation. Mechanistically, we demonstrated that CIC represses VGF expression by tethering SIN3-HDAC to form a transcriptional corepressor complex. Mass spectrometry analysis of CIC-interacting proteins further identified the BRG1-containing mSWI/SNF complex whose function is necessary for transcriptional repression by CIC. Together, this study uncovers a potentially novel regulatory pathway of CIC-dependent neuronal differentiation and may implicate these molecular mechanisms in CIC-dependent brain tumorigenesis.

| S-EPMC7253013 | biostudies-literature

Differentiation enhances Zika virus infection in neuronal brain cells

Project description:Differentiation enhances Zika virus infection in neuronal brain cells

| PRJNA497590 | ENA