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Phospho-antibody microarray analyses for islets of control and Mettl14 knock-out mice

ABSTRACT: Phospho-antibody microarray analyses for islets of control and Mettl14 knock-out mice

PROVIDER: PRJNA545963 | ENA |

REPOSITORIES: ENA

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Phospho-antibody microarray analyses for islets of control and Mettl14 knock-out mice

Project description:β-cell specific Mettl14 knock-out mice display reduced N6-methyladenosine (m6A) levels and recapitulate human Type II diabetes (T2D) islet phenotype with early diabetes onset and mortality secondary to decreased β-cell proliferation and insulin degranulation. To gain insights into the role of m6A in regulating the IGF1/insulin -> AKT - > PDX1 pathway and to dissect the signaling networks modulating AKT phosphorylation, we subjected freshly isolated islets from control and Mettl14 knock-out mice to phospho-antibody microarrays.

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Phospho-antibody microarray analyses for islets of control and IFT88 knockout mice [PEX100]

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m6A-sequencing of Mettl14-conditional knock-out retinas and matched control.

Project description:Post-transcriptional m6A methylation on mRNA plays a key role in neural development. Here, we specifically depleted Mettl14 (a key component of m6A complex) in retina progenitor cells by crossing Mettl14 fl/fl mice with the Chx10-Egfp/Cre mouse line and investigated Mettl14 depletion-induced m6A alteration in developing retinas using m6A-seq.

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m6A-sequencing of Mettl14-conditional knock-out retinas and matched control.

Project description:m6A-sequencing of Mettl14-conditional knock-out retinas and matched control.

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Phospho-antibody microarray analyses for islets of control and IFT88 knockout mice [PEX100]

Project description:Phospho-antibody microarray analyses for islets of control and IFT88 knockout mice [PEX100]

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Single-cell RNA-sequencing of Mettl14 conditional knock-out retinas and matched controls

Project description:Post-transcriptional m6A methylation on mRNA plays a key role in neural development. Here, we specifically depleted Mettl14 (a key component of m6A complex) in retina progenitor cells by crossing Mettl14 fl/fl mice with the Chx10-Egfp/Cre mouse line and investigated cell type and transcriptome changes in the developing retinas using scRNA-seq.

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Identifying metabolite changes in human islets treated with Phospho-BAD mimicry and Inflammatory cytokines

Project description:The goal of this study was to associate metabolite changes with protection of human islets from cell death induced by the diabetogenic stress of inflammatory cytokines. Protection of human islet viability was accomplished via enhanced glucose metabolism using phospho-BAD mimicry peptide treatment.

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Effect of Fzd9 knock-out on MycER-BclXl insulinoma progression

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